Abstract
Question: In children under 16 is fluoride varnish effective in preventing caries?
Objective To determine the effectiveness and safety of fluoride varnishes in the prevention of dental caries in children and to examine factors potentially modifying their effect.
Data sources The reviewers attempted to identify all relevant studies irrespective of language, from 1965 onwards. Multiple electronic database were searched together with reference lists of articles, prospective hand searches of the journals identified as publishing the most eligible trials, and searches for selected authors and manufacturers.
Study selection Randomised or quasi-randomised controlled trials were included if they had blind outcome assessment and compared fluoride varnish with placebo or no treatment in children up to 16 years old for at least 1 year. The main outcome was caries increment measured by the change in decayed, missing and filled tooth surfaces (DMFS).
Data extraction and synthesis Inclusion decisions, quality assessment and data extraction were duplicated in a random sample of one third of studies, and consensus was achieved by discussion with a third party. Study authors were contacted for missing data. The primary measure of effect was the prevented fraction (PF), that is, the difference in caries increments between the treatment and control groups expressed as a proportion of the increment in the control group. Random effects meta-analyses were performed where data could be pooled. Potential sources of heterogeneity were examined in random-effects meta-regression analyses.
Results Nine studies were included, involving 2709 children. Seven contributed data for the main meta-analysis. There was substantial heterogeneity. The estimated pooled prevented fraction for permanent teeth was 46% (95% CI 30–63) and 33% (95% CI 19–48) for deciduous teeth. No significant association between estimates of dfs, DMFS, PF and baseline caries severity or background exposure to fluorides was found in meta-regression, and a funnel plot of the seven studies indicated no relationship between PF and study precision. In both methods, power is limited when only a few trials are included.
Conclusions The review suggests a substantial caries-inhibiting effect of fluoride varnish in both the permanent and the deciduous dentitions based largely on trials that had no treatment controls. There is little information concerning acceptability of treatment or possible side-effects in the trials included. Given the relatively poor quality of most of the studies and the wide confidence intervals around the estimates of effect, there remains a need for further trials of high quality that include assessment of potential adverse effects.
Marinho VCC, Higgins JPT, Logan S, Sheiham A. Fluoride varnishes for preventing dental caries in children and adolescents (Cochrane Review). The Cochrane Library 2002; Issue 3. Oxford: Update Software
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Address for correspondence: Emma Tavender, Cochrane Oral Health Group, MANDEC, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH, UK. E-mail: emma.tavender@man.ac.uk
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Bader, J. A substantial caries-inhibiting effect of fluoride varnish is suggested. Evid Based Dent 3, 105–106 (2002). https://doi.org/10.1038/sj.ebd.6400142
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DOI: https://doi.org/10.1038/sj.ebd.6400142
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