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The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus

Genes & Immunity volume 7, pages 327–334 (2006)Cite this article

Abstract

To date, three loci have been validated to confer susceptibility to inflammatory bowel disease (IBD): the CARD15/NOD2 gene, the discs large homolog 5 gene (DLG5), and the IBD5 locus on 5q31 (IBD5). We have explored the possibility that these loci may also be associated with susceptibility to two other chronic inflammatory diseases, multiple sclerosis (MS) and systemic lupus erythematosus (SLE). As the CARD15 risk alleles had previously been assessed in our collection of 496 MS trios, we focused our efforts on the DLG5 risk allele and the IBD5risk haplotype (IBD5risk) for MS. While there is no evidence of association within our MS sample with either of these polymorphisms, screening of 1027 subjects with SLE suggests that IBD5risk may have a modest contribution to disease risk in the subset of SLE subjects without lupus nephritis. In addition, a pooled analysis of existing published and unpublished data in 1305 cases of SLE genotyped for the CARD15 risk alleles suggests that only the CARD15908R IBD risk allele may have a strong effect on risk of SLE. Our data, therefore, suggest that both the CARD15 gene and the IBD5 locus may have a role as general susceptibility loci for certain common, genetically complex inflammatory diseases.

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Acknowledgements

PLD is the William C Fowler scholar in Multiple Sclerosis and is supported by an NINDS K08 grant as well as the Clinical Investigator Training Program: Harvard-MIT Health Sciences and Technology Beth Israel Deaconess Medical Center, in collaboration with Pfizer, Inc. JDR is supported by grants from the NIDDK and the CCFA.

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Authors and Affiliations

  1. Department of Neurology, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA

    P L De Jager, D A Hafler & J D Rioux

  2. Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA

    P L De Jager, R Graham, L Farwell, A Richardson, D A Hafler & J D Rioux

  3. University of Cambridge Department of Clinical Neurosciences, Addenbrooke's, Hospital, Cambridge, UK

    S Sawcer & A Compston

  4. Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA

    T W Behrens

  5. Department of Medical Genetics, University of Helsinki, Helsinki, Finland

    J Kere

  6. Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK

    T J Vyse

  7. Montréal Heart Institute, Montréal, Québec, Canada

    J D Rioux

  8. Université de Montréal, Montréal, Québec, Canada

    J D Rioux

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  1. P L De Jager
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  2. R Graham
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  4. S Sawcer
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Correspondence to J D Rioux.

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De Jager, P., Graham, R., Farwell, L. et al. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes Immun 7, 327–334 (2006). https://doi.org/10.1038/sj.gene.6364303

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