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Tunisian endemic pemphigus foliaceus is associated with desmoglein 1 gene polymorphism

Genes & Immunity volume 3, pages 378–379 (2002)Cite this article

Abstract

Desmoglein 1 is the target antigen and probably the initiating immunogen of the autoantibody response in pemphigus foliaceus (PF), a blistering autoimmune skin disease. We previously showed that the desmoglein 1 gene (DSG1) is polymorphic and that one of its variants is associated with the sporadic form of PF observed in France. Herewith, we report, based on a case–control analysis, that the same DSG1 polymorphism participates in susceptibility to the endemic form of PF seen in Tunisia and, thus, show that common genetic factors govern the breakage of tolerance to desmoglein 1 in different epidemiological and environmental situations.

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Authors and Affiliations

  1. Laboratoire d’Immunologie, CHU Hedi Chaker, Sfax, Tunisia

    M B Ayed & H Masmoudi

  2. INSERM U519, Institut Fédératif de Recherche Multidisciplinaire sur les Peptides, Faculté de Médecine et de Pharmacie, Rouen, France

    P Martel, D Gilbert & F Tron

  3. Laboratoire d’Immunologie, Hôpital La Rabta, Tunis, Tunisia

    M Zitouni & S Makni

  4. Service de Dermatologie, CHU Hédi Chaker, Sfax, Tunisia

    H Turki & A Zahaf

  5. Service de Dermatologie, CHU La Rabta, Tunis, Tunisia

    M Mokni & A B Osman

  6. Service de Dermatologie, Hôpital Charles Nicolle, Tunis, Tunisia

    M R Kamoun

Authors
  1. M B Ayed
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  2. P Martel
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  3. M Zitouni
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  4. D Gilbert
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  5. H Turki
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  6. M Mokni
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  7. A B Osman
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  8. M R Kamoun
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  9. A Zahaf
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  10. S Makni
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  11. H Masmoudi
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  12. F Tron
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Corresponding author

Correspondence to F Tron.

Additional information

This work was supported by a grant from INSERM/DGRST (1999–2000) France–Tunisie.

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Ayed, M., Martel, P., Zitouni, M. et al. Tunisian endemic pemphigus foliaceus is associated with desmoglein 1 gene polymorphism. Genes Immun 3, 378–379 (2002). https://doi.org/10.1038/sj.gene.6363868

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  • DOI: https://doi.org/10.1038/sj.gene.6363868

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