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Novel polymorphisms in human macrophage inflammatory protein-1 alpha (MIP-1α) gene

Genes & Immunity volume 2, pages 156–158 (2001)Cite this article

Abstract

Human macrophage inflammatory protein-1 alpha (MIP-1α) is a chemotactic cytokine, which binds to macrophages, T cells, and B cells affecting their activation. We found novel polymorphisms at four sites within MIP-1α gene in Japanese population: C to T in exon 2; A to G in intron 2; C to G and A to G in exon 3. They occurred on the same allele. Although MIP-1α effectively suppresses the replication of HIV-1 in vitro, we observed no statistically significant difference in the allele frequency of this polymorphism between HIV-1-infected and uninfected individuals in Japanese population. Since an increased transcription level of MIP-1α has been reported to be associated with inflammatory diseases such as atopic dermatitis, we also investigated the frequency of these polymorphisms among patients with atopic dermatitis, HIV-1-infected individuals (with a normal IgE level), and healthy donors. A small increase in ratio of homozygotes to other genotypes was observed in patients with atopic dermatitis (P = 0.04).

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Acknowledgements

We thank Drs Ai Tachikawa, Tomohiko Koibuchi, and Mioo Satoh for clinical samples and data, and Dr Deshan Yu for discussion.

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Authors and Affiliations

  1. Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    X Xin, M Goto, Y Kitamura & A Iwamoto

  2. Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    K Nakamura

  3. Department of Immune and Living Body Defense, Institute of Microbal Disease, Osaka University, Japan

    H Liu, EE Nakayama & T Shioda

  4. National Institute of Infectious Disease, Tokyo, Japan

    Y Nagai

Authors
  1. X Xin
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  2. K Nakamura
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  3. H Liu
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  4. EE Nakayama
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  6. Y Nagai
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  7. Y Kitamura
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  8. T Shioda
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  9. A Iwamoto
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Corresponding author

Correspondence to Y Kitamura.

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This work was supported by grants from Ministry of Education, Science, Sports, and Culture; the Ministry of Health and Welfare; and Japan Society for the Promotion of Science.

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Xin, X., Nakamura, K., Liu, H. et al. Novel polymorphisms in human macrophage inflammatory protein-1 alpha (MIP-1α) gene. Genes Immun 2, 156–158 (2001). https://doi.org/10.1038/sj.gene.6363759

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  • DOI: https://doi.org/10.1038/sj.gene.6363759

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