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Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population

Genes & Immunity volume 2, pages 233–235 (2001)Cite this article

Abstract

Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.

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Acknowledgements

We thank nurse Oonagh McGlone for recruiting and sampling patients and their families. We are also extremely grateful to those clinicians who assisted us in recruitment of subjects.

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Authors and Affiliations

  1. Department of Medical Genetics, The Queen’s University of Belfast, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, Northern Ireland

    RM McCormack & DA Savage

  2. Regional Nephrology Unit, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, Northern Ireland

    AP Maxwell

  3. Department of Child Health, The Queen’s University of Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BL, Northern Ireland

    D Carson & A Bingham

  4. Department of Epidemiology & Public Health, The Queen’s University of Belfast, Mulhouse Building, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland

    CC Patterson

Authors
  1. RM McCormack
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  2. AP Maxwell
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  3. D Carson
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  4. CC Patterson
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  5. A Bingham
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  6. DA Savage
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Corresponding author

Correspondence to DA Savage.

Additional information

We thank the Northern Ireland Kidney Research Fund for supporting Rose McCormack and the Dinah Kohner Fund, the Northern Ireland Kidney Research Fund and Royal Belfast Hospital for Sick Children for funding Oonagh McGlone

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McCormack, R., Maxwell, A., Carson, D. et al. Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population . Genes Immun 2, 233–235 (2001). https://doi.org/10.1038/sj.gene.6363749

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  • DOI: https://doi.org/10.1038/sj.gene.6363749

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