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A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes

Genes & Immunity volume 2, pages 290–291 (2001)Cite this article

Abstract

In the current study, we report a G to A single nucleotide polymorphism at base pair 396 of the TCRBV5S5P gene. This polymorphism has a frequency of 0.20 in a cohort of Caucasian controls. In addition, we provide evidence for linkage disequilibrium between TCRBV5S5P and the TCRBV6S1 gene.

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References

  1. Arden B, Clark SP, Kabelitz D, Mak TW Human T-cell receptor variable gene segment families Immunogenetics 1995 42 455–500

    CAS  PubMed  Google Scholar 

  2. Wei S, Charmley P, Robinson MA, Concannon P The extent of the human germline T-cell receptor V beta gene segment repertoire Immunogenetics 1994 40 27–36

    Article  CAS  PubMed  Google Scholar 

  3. Luyrink L, Gabriel CA, Thompson SD et al Reduced expression of a human Vβ6.1 T-cell receptor allele Proc Natl Acad Sci USA 1993 90 4369–4373

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Barron KS, Robinson MA The human T-cell receptor variable gene segment TCRBV6S1 has two null alleles Hum Immunol 1994 40 17–19

    Article  CAS  PubMed  Google Scholar 

  5. Terwilliger J, Ott J Handbook of Human Genetic Linkage Johns Hopkins University Press: Baltimore 1994

    Google Scholar 

  6. Lewontin RC The interaction of selection and linkage I. General considerations, heterotic models Genetics 1964 49 49–67

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Grom AA, von Knorre C, Murray KJ, Donnelly PA, Glass DN, Choi E T-cell receptor BV6S1 null alleles and HLA-DR1 haplotypes in polyarticular outcome juvenile rheumatoid arthritis Hum Immunol 1996 45 152–156

    Article  CAS  PubMed  Google Scholar 

  8. Charmley P, Nepom BS, Concannon P HLA and T-cell receptor β-chain DNA polymorphisms identify a distinct subset of patients with pauciarticular-onset juvenile rheumatoid arthritis Arthritis Rheum 1994 37 695–701

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors wish to thank Mehdi Keddache from the Department of Pediatrics, Division of Human Genetics, Children’s Hospital Research Foundation of Cincinnati for assistance with the EH software analysis.

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Authors and Affiliations

  1. Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    JL Brzezinski & E Choi

  2. Department of Pediatrics, William S. Rowe Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, OH, USA

    DN Glass

Authors
  1. JL Brzezinski
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  2. DN Glass
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  3. E Choi
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Corresponding author

Correspondence to E Choi.

Additional information

This work was supported, in part, by National Institutes of Health grants AR44059 and AR44566, the Schmidlapp Foundation, and the Children’s Hospital Research Foundation of Cincinnati

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Brzezinski, J., Glass, D. & Choi, E. A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes . Genes Immun 2, 290–291 (2001). https://doi.org/10.1038/sj.gene.6363748

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  • DOI: https://doi.org/10.1038/sj.gene.6363748

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