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SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency

Genes & Immunity volume 1, pages 191–199 (2000)Cite this article

Abstract

Lymphotoxin (LT) deficient mice have profound defects in the splenic microarchitecture associated with defective expression on certain gene products, including chemokines. By using subtraction cloning of splenic cDNA from wild-type and LTα or TNF/LTα double deficient mice we isolated a novel murine gene encoding a secretory type phospholipase A2, called SPLASH. The two major alternative transcripts of SPLASH gene are predominantly expressed in lymphoid tissues, such as spleen and lymph nodes. SPLASH maps to the distal part of chromosome 4, to which several cancer-related loci have been also mapped.

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Authors and Affiliations

  1. Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick and Laboratory of Molecular Immunoregulation, NCI-FCRDC, Frederick, 21702, MD, USA

    AN Shakhov, AV Rubtsov, IG Lyakhov, AV Tumanov & SA Nedospasov

  2. Institute of Toxicology, ETH, Schwerzenbach, Switzerland

    AN Shakhov

  3. Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 117984 and Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119899, Russia

    AV Rubtsov, AV Tumanov & SA Nedospasov

Authors
  1. AN Shakhov
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  2. AV Rubtsov
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  3. IG Lyakhov
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  4. AV Tumanov
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  5. SA Nedospasov
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Correspondence to AN Shakhov.

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The publisher or recipient acknowledges right of the US Government to retain a non-exclusive, royalty-free license in and to any copyright covering the article.

This project has been funded in whole or in part with US Federal funds from the National Cancer Institute, National Institutes of Health (contract NO1-CO-56000), by Grant SNF 31–37490.93 from Swiss National Fund, 98–04–49029 from the Russian Foundation for Basic Research and by a grant from Russian State Program ‘Frontiers in Genetics’. S.A.N. is International Research Scholar of the Howard Hughes Medical Institute. A.V.R. was supported by ICRETT Fellowship from International Union Against Cancer (Geneva).

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Shakhov, A., Rubtsov, A., Lyakhov, I. et al. SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency. Genes Immun 1, 191–199 (2000). https://doi.org/10.1038/sj.gene.6363659

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  • DOI: https://doi.org/10.1038/sj.gene.6363659

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