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Abstract
Chemotherapy for non-Hodgkin's lymphoma (NHL) may affect tooth formation.
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Oğuz A, Çetiner S et al. Eur J Oral Sci 2004; 112: 8–11
This study compared dental development malformations in 36 long-term survivors of childhood NHL and a matched control group of 36. The mean age at diagnosis of NHL was 7.1 yrs (range 3.2-15), and at the time of the dental assessment, 10 yrs (4.2-17.6). Chemotherapy had ceased 1 to 6.2 years earlier (mean 2.6).
The control group differed from the NHL group solely in having a lower mean Plaque Index (0.9 v. 1.49). Gingival Index and dmft/DMFT were similar. Enamel discoloration affected 67% of the NHL group, and 25% of the controls (P = 0.0001). Root malformation was found respectively in 44% and 25% (P = 0.02). There were no significant differences between groups in enamel defects, unerupted teeth, agenesis, premature apexification and microdontia, nor between children over and under the age of 5 yrs at NHL diagnosis.
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Long-term effects of chemotherapy on orodental structures in children with non-Hodgkin's lymphoma. Br Dent J 197, 547 (2004). https://doi.org/10.1038/sj.bdj.4811803
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DOI: https://doi.org/10.1038/sj.bdj.4811803