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Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/ml

Prostate Cancer and Prostatic Diseases volume 9, pages 235–238 (2006)Cite this article

Abstract

We investigated the effect of prostatic inflammation on prostate-specific antigen (PSA) and per cent-free PSA levels changing after antibacterial therapy. We evaluated 48 patients whose PSA levels were between 4 and 10 ng/ml, without any suspicious findings on digital rectal examination, with no infection findings in urine analysis. Prostatic inflammation was assessed with prostatic massage. All the patients were given antibiotic therapy for 3 weeks. Patients were re-evaluated 3 weeks after antibacterial therapy with PSA (free/total) and urinalysis. Ten core biopsies were taken with transrectal ultrasound. No differences were found in terms of age, pre- and post-treatment PSA, and PSA varying between patients with and without inflammation in the prostatic massage. In 18 patients, PSA decreased below 4 ng/ml. Prostate cancer was found in 10.8% of the patients with PSA between 4 and 10 ng/ml and none of the patients with PSA values below 4 ng/ml. We suggest an antibiotic therapy for 3 weeks without regarding inflammation findings when PSA is in the gray zone, for biopsy decision.

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  1. Department of Urology, Ankara Numune Education and Research Hospital, Ankara, Turkey

    O Kaygısız, Ö Uğurlu, M Koşan, G İnal, B Öztürk & M Çetinkaya

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  1. O Kaygısız
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  2. Ö Uğurlu
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  3. M Koşan
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  4. G İnal
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Correspondence to O Kaygısız.

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Kaygısız, O., Uğurlu, Ö., Koşan, M. et al. Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/ml. Prostate Cancer Prostatic Dis 9, 235–238 (2006). https://doi.org/10.1038/sj.pcan.4500885

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