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Hypertriglyceridemia as a possible risk factor for prostate cancer

Prostate Cancer and Prostatic Diseases volume 8, pages 316–320 (2005)Cite this article

Abstract

We retrospectively studied anthropometric and laboratory parameters (including serum triglycerides, cholesterol), as well as comedication in 504 patients diagnosed with prostate cancer between January 1997 and August 2002 at a single referral center, and compared these patients with 565 age-matched patients with benign prostatic hyperplasia. A positive correlation was found between serum triglycerides and prostate cancer (odds ratio: 1.148/mmol/l; 95% confidence interval (CI) 1.003–1.315; P<0.05) after correcting for age, body mass index, diabetes and comedication with statins. Hypertriglyceridemia may increase the risk of prostate cancer, and the prognostic relevancy of serum triglycerides should be studied prospectively.

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Acknowledgements

M Joerger is supported by a fellowship grant funded by the European Society of Medical Oncology and by a research grant from the Swiss National Science Foundation (PBBSB-102331).

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Author notes

  1. L Wuermli and M Joerger: These two authors contributed equally to this publication

Authors and Affiliations

  1. Department of Internal Medicine, Kantonsspital St.Gallen, Switzerland

    L Wuermli & S Henz

  2. Division of Experimental Therapy, Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands

    M Joerger

  3. Department of Urology, Kantonsspital St Gallen, Switzerland

    H-P Schmid

  4. Department of Clinical Chemistry and Hematology, Kantonsspital St Gallen, Switzerland

    W F Riesen

  5. Genome Research Institute, University of Cincinnati, USA

    G Thomas

  6. Institute of Cell Biology, ETH Hoenggerberg, Zuerich, Switzerland

    W Krek

  7. Department of Medical Oncology, Kantonsspital St Gallen, Switzerland

    T Cerny & S Gillessen

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  1. L Wuermli
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Correspondence to M Joerger.

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Wuermli, L., Joerger, M., Henz, S. et al. Hypertriglyceridemia as a possible risk factor for prostate cancer. Prostate Cancer Prostatic Dis 8, 316–320 (2005). https://doi.org/10.1038/sj.pcan.4500834

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  • DOI: https://doi.org/10.1038/sj.pcan.4500834

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