Abstract
Despite improvements in treatment of localized prostate cancer, local recurrence remains a significant problem. A total of 46 patients with proven local cancer recurrence following external beam radiotherapy entered a prospective clinical trial using ultrasound-guided cryosurgery to ablate the residual prostate gland. Persistent complications included one urethra–rectal fistula, incontinence (2), retention (3), and treatment induced erectile dysfunction (7). Using the PSA definitions for biochemical failure as PSA ⩾0.3 ng/ml, the Kaplan–Meier plots showed the incidence of patients to be free of biochemical recurrence at 51 and 44% at 1 and 2 y, respectively. For a PSA ⩾1.0, the values at 1 and 2 y were 72 and 58%.
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This research was supported by a grant from the Alberta Cancer Board.
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Donnelly, B., Saliken, J., Ernst, D. et al. Role of transrectal ultrasound guided salvage cryosurgery for recurrent prostate carcinoma after radiotherapy. Prostate Cancer Prostatic Dis 8, 235–242 (2005). https://doi.org/10.1038/sj.pcan.4500811
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DOI: https://doi.org/10.1038/sj.pcan.4500811
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