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High risk genes predisposing to prostate cancer development—do they exist?

Prostate Cancer and Prostatic Diseases volume 3, pages 241–247 (2000)Cite this article

Abstract

There is evidence for genetic predisposition to prostate cancer. However, prostate cancer genes have been more difficult to find than genes for some of the other common cancers, such as breast and colon cancer. The reasons for this are discussed in this article and it is now becoming clear that prostate cancer is probably due to multiple genes, many of which are moderate or low penetrance. The advances in the Human Genome Project and technology, especially that of robotics, will help to overcome these problems.

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Author notes

  1. R Singh, RA Eeles, F Durocher, J Simard, S Edwards, M Badzioch, Z Kote-Jarai, D Teare, D Ford, D Dearnaley, A Ardern-Jones, A Murkin, A Dowe, R Shearer, J Kelly, F Labrie, D Easton, SA Narod, PN Tonin and WD Foulkes: List of collaborators available on request.

Authors and Affiliations

  1. Institute of Cancer Research, Sutton, Surrey, UK

    R Singh, RA Eeles, S Edwards, Z Kote-Jarai, D Ford, D Dearnaley & J Kelly

  2. Royal Marsden NHS Trust, Sutton, Surrey, UK

    RA Eeles, D Dearnaley, A Ardern-Jones, A Murkin, A Dowe & R Shearer

  3. Laboratory of Molecular Endocrinology, CHUL Research Center, Quebec City, Quebec, Canada

    F Durocher, F Durocher, J Simard, F Labrie & PN Tonin

  4. MD Anderson Cancer Centre, Houston, Texas, USA

    M Badzioch

  5. CRC Genetic Epidemiology Unit, Strangeways Research Laboratories, Cambridge, UK

    D Teare & D Easton

  6. Centre for Research in Women's Health, Toronto, Ontario, Canada

    SA Narod

  7. Department of Medicine, Montreal General Hospital, Montreal, Quebec, Canada

    WD Foulkes

  8. Division of Medical Genetics, Box 35 7720, University of Washington Medical Center, Seattle, 98195, WA, USA

    M Badzioch

Authors
  1. R Singh
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  2. RA Eeles
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  3. F Durocher
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  4. J Simard
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  5. S Edwards
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  6. M Badzioch
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  7. Z Kote-Jarai
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  8. D Teare
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  9. D Ford
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  10. D Dearnaley
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  11. A Ardern-Jones
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  12. A Murkin
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  13. A Dowe
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  14. R Shearer
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  15. J Kelly
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  16. F Labrie
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  17. D Easton
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  18. SA Narod
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  19. PN Tonin
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  20. WD Foulkes
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Consortia

The CRC/BPG UK Familial Prostate Cancer Study Collaborators

Corresponding author

Correspondence to RA Eeles.

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Singh, R., Eeles, R., Durocher, F. et al. High risk genes predisposing to prostate cancer development—do they exist?. Prostate Cancer Prostatic Dis 3, 241–247 (2000). https://doi.org/10.1038/sj.pcan.4500478

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  • DOI: https://doi.org/10.1038/sj.pcan.4500478

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