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Cell adhesion and chemotaxis in prostate cancer metastasis to bone: a minireview

Prostate Cancer and Prostatic Diseases volume 3, pages 6–12 (2000)Cite this article

Abstract

Bone metastasis is a common phenomenon in patients with advanced prostate cancer. The molecular and cellular mechanisms involved in this process are not well understood. Past reviews on this subject primarily focused on prostate tumor growth in the bone marrow and the effects this growth has on bone homeostasis (ie osteoblastic and osteolytic). Cell chemotaxis and adhesion are also important for site-specific metastasis. In this review we have focused on chemotactic and cell adhesion molecules potentially involved in prostate cancer metastasis to bone. In addition, recently developed animal models for prostate cancer metastasis to bone are discussed.

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  1. Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, 48109, MI, USA

    CR Cooper & KJ Pienta

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  1. CR Cooper
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  2. KJ Pienta
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Correspondence to CR Cooper.

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Cooper, C., Pienta, K. Cell adhesion and chemotaxis in prostate cancer metastasis to bone: a minireview. Prostate Cancer Prostatic Dis 3, 6–12 (2000). https://doi.org/10.1038/sj.pcan.4500387

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  • DOI: https://doi.org/10.1038/sj.pcan.4500387

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