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Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

Abstract

Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age- and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.

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Acknowledgements

This study was supported by grants from the Deutsche Forschungsgemeinschaft (WE 3638/1-1 to MW), the French National Academy of Medicine (to JH), the French Institute for Health and Medical Research (RBM 04-27 and AP-HP/INSERM interface research grant 2003 to MLPM) and ANR grant ‘PSY-marker’ (Agence Nationale pour la Recherche). We thank Jean-Francois Mangin and Yann Cointepas for methodological assistance and helpful comments on the manuscript.

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Correspondence to M Wessa.

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Supplementary Information accompanies the paper on the Molecular Psychiatry website (http://www.nature.com/mp)

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Houenou, J., Wessa, M., Douaud, G. et al. Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex. Mol Psychiatry 12, 1001–1010 (2007). https://doi.org/10.1038/sj.mp.4002010

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Keywords

  • anisotropy
  • diffusion magnetic resonance imaging
  • humans
  • adult
  • bipolar disorder

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