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CART peptide levels are altered by a mutation associated with obesity at codon 34

Molecular Psychiatry volume 9, pages 1065–1066 (2004)Cite this article

SIR—CART is a regulated neuropeptide that plays a role in many physiological processes including stress, reward and reinforcement and feeding.1, 2, 3 Recently, del Giudice et al4 described a missense mutation at codon 34 of proCART that cosegregated with severe early-onset obesity. Our findings show here for the first time that this mutation has a biochemical effect and alters CART peptide levels in cells.

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Acknowledgements

This work was supported by NIH grants RR00165, DA00418 and DA15162.

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Authors and Affiliations

  1. Division of Neuroscience, Yerkes National Primate Research Center of Emory University, Atlanta, GA, USA

    G Dominguez & M J Kuhar

  2. Department of Pediatrics, Second University of Naples, Naples, Italy

    E M del Giudice

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  1. G Dominguez
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  2. E M del Giudice
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  3. M J Kuhar
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Correspondence to G Dominguez.

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Dominguez, G., del Giudice, E. & Kuhar, M. CART peptide levels are altered by a mutation associated with obesity at codon 34. Mol Psychiatry 9, 1065–1066 (2004). https://doi.org/10.1038/sj.mp.4001578

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