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Glial cell dysfunction in schizophrenia indicated by increased S100B in the CSF

Molecular Psychiatry volume 9, pages 897–899 (2004)Cite this article

SIR—Findings from neuropathological and imaging studies reveal a reduction of neuropil in schizophrenia that might even have a progressive component. Neuronal cell sizes as well as dendrite and synapse numbers are decreased while neuronal counts remain unchanged.1, 2 Until recently, astrocytes were merely regarded as metabolic supporters of neurons. Advanced research, however, has revealed evidence that a dysfunction of astrocytes can be directly responsible for neuronal malfunction and might therefore play a key role in the development of schizophrenia. Astrocytes influence dendrites and synapses mainly via glutamate-induced Ca2+ modulation (for a review, see Araque et al3).

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Acknowledgements

This study was supported by the Innovative Medical Research Program of the University of Muenster (RO 2 1 99 19).

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Authors and Affiliations

  1. Department of Psychiatry, University of Muenster, Germany

    M Rothermundt, G Ponath, S Abel, M Diedrich, G Hetzel, M Peters, A Siegmund, A Pedersen, T Suslow, P Ohrmann & V Arolt

  2. Department of Psychiatry, University of Saarland, Germany

    P Falkai

  3. Department of Anesthesiology and Intensive Care, University of Muenster, Germany

    H Bürkle

  4. Department of Psychiatry, University of Bonn, Germany

    W Maier

  5. Department of Neurosurgery, University of Bonn, Germany

    J Schramm

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  1. M Rothermundt
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  2. P Falkai
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  3. G Ponath
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  4. S Abel
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Correspondence to M Rothermundt.

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Rothermundt, M., Falkai, P., Ponath, G. et al. Glial cell dysfunction in schizophrenia indicated by increased S100B in the CSF. Mol Psychiatry 9, 897–899 (2004). https://doi.org/10.1038/sj.mp.4001548

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