A recent study has suggested that the brain-expressed genes for G72 and D-amino-acid oxidase (DAAO) exert an influence on susceptibility to schizophrenia. Our aim was to replicate this finding in German schizophrenic patients and to assess whether G72 and DAAO might also contribute to the development of bipolar affective disorder. We genotyped seven single-nucleotide polymorphisms (SNPs) in the G72 gene and three in the DAAO gene in 599 patients (299 schizophrenic, 300 bipolar) and 300 controls. At G72, individual SNPs and a four-marker haplotype were associated with schizophrenia. The most significant SNP as well as the haplotype were also associated with bipolar affective disorder (BPAD). DAAO was associated with schizophrenia, but not with BPAD. The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background.
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This study was supported by the National Genomic Network (NGFN) of the German Ministry of Education and Research, the SFB 400 of the German Research Council (DFG), the Fund for Scientific Research Flanders (FWO, Grants G.0425.02 and G0438.03), the Belgium Interuniversity Attraction Pole (IUAP ‘Molecular Genetics and Cell Biology’) and a Concerted Research Project (GOA) by the University of Antwerp. AVDB holds a predoctoral position with the Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT). We thank Dr E Hattori for communicating primer sequences for SNPs rs1341402 and rs1935062.
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Schumacher, J., Abon Jamra, R., Freudenberg, J. et al. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry 9, 203–207 (2004). https://doi.org/10.1038/sj.mp.4001421
- bipolar affective disorder
- G72; DAAO
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