Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

No association of alcohol dependence with a NMDA-receptor 2B gene variant

Molecular Psychiatry volume 8, pages 11–12 (2003)Cite this article

SIR – Alcohol dependence is a disorder with strong genetic influences and heritability estimates ranging between 40 and 60%.1 Recent results have demonstrated the importance of ethanol-induced glutamatergic neurotransmission for the development of alcohol dependence. Ethanol-induced glutamatergic neurotransmission has been shown to influence pathophysiological mechanisms central to the development of alcohol dependence, including tolerance, withdrawal symptoms, craving and ethanol-related neurotoxicity.2 We performed an association study of alcohol dependence and a silent single nucleotide polymorphism (SNP) of the N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) subunit leading to a C to T exchange at position 2873 of the gene (accession number XM 006636.2).3 A total of 204 patients (157 males, 47 females) with alcohol dependence according to DSM-IV criteria and 258 unrelated control subjects (138 males, 120 females) were included in the study.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. Schuckit MA . Am J Addict 2000; 9: 103–112.

    Article  CAS  Google Scholar 

  2. Fadda F et al. Prog Neurobiol 1998; 56: 385–431.

  3. Nishiguchi N et al. Am J Psychiatry 2000; 157: 1329–1331.

  4. Fink K et al. Naunyn Schmiedebergs Arch Pharmacol 1996; 354: 312–319.

  5. Tsai G et al. Am J Psychiatry 1995; 152: 332–340.

  6. Masood K et al. Mol Pharmacol 1994; 45: 324–329.

  7. Narita M et al. Eur J Pharmacol 2000; 401: 191–195.

  8. Williams K et al. Mol Pharmacol 1994; 45: 803–809.

  9. Selzer ML . Am J Psychiatry 1971; 127: 1653–1658.

  10. Wittchen HU . J Psychiat Res 1994; 28: 57–84.

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Central Institute of Mental Health (CIMH), Mannheim, Germany

    G Schumann & F A Henn

  2. Department of Psychiatry and Psychotherapy, Molecular Neurobiology, University of Munich, Germany

    D Rujescu & I Giegling

  3. Department of Psychiatry and Psychotherapy, University of Mainz, Germany

    A Szegedi, P Singer, C Klawe & N Dahmen

  4. Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany

    S Wiemann

  5. Department of Biostatistics, CIMH, Mannheim

    S Wellek

  6. Department of Psychiatry, Benjamin-Franklin Hospital, Free University, Berlin

    I Anghelescu

  7. Department of Psychiatry, Charité, Humboldt University, Berlin

    A Heinz

  8. Department of Psychopharmacology CIMH, Mannheim

    R Spanagel

  9. Department of Addictive Behaviour and Addiction Medicine, CIMH, Mannheim, Germany

    K Mann

Authors
  1. G Schumann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D Rujescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Szegedi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P Singer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Wiemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S Wellek
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. I Giegling
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. C Klawe
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. I Anghelescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A Heinz
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. R Spanagel
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. K Mann
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. F A Henn
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. N Dahmen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G Schumann.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schumann, G., Rujescu, D., Szegedi, A. et al. No association of alcohol dependence with a NMDA-receptor 2B gene variant. Mol Psychiatry 8, 11–12 (2003). https://doi.org/10.1038/sj.mp.4001245

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4001245

This article is cited by

Search

Advanced search

Quick links