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Map of candidate genes and STSs on 18p11.2, a bipolar disorder and schizophrenia susceptibility region

Molecular Psychiatry volume 7, pages 337–339 (2002)Cite this article

Sir – Linkage and association studies suggest an overlap of bipolar disorder and schizophrenia susceptibility regions on chromosome 18p.1,2,3,4 Fine genetic mapping revealed the highest evidence of linkage at 18p11.2.5 Located in this region are GNAL and IMPA2, alleles of which have been associated with schizophrenia,2,4 raising the possibility of at least one predisposing gene for a major psychiatric disorder in the region. But, if neither GNAL nor IMPA2 is the susceptibility gene, then it is essential to identify and systematically scrutinize all candidate genes on 18p11.2 for risk-conferring mutations. To investigate this region further, we constructed an array of overlapping BAC and PAC clones spanning ∼ 8 cM region flanked by pter-D18S464 and D18S360E-pcen. Included in the contig were 16 BACs and four PACs upon which 47 sequence tag sites (STSs) were mapped through PCR. A total of 29 new STSs generated from BAC/PAC insert ends were used to facilitate chromosome walking and ordering of clones.

The availability of the first draft of the human genome sequence6,7 permits determination of the position and order of candidate genes and new STSs. By using these sequences to conduct BLAST analysis on the National Center for Biotechnology Information (NCBI) database,8 we found that the D18S464 and D18S360E interval is covered by six contigs, arranged in the following order: pter—NT_010870 (901 kb)—NT_025037 (229.7 kb)—NT_019631 (969.3 kb)—NT_010956 (1139 kb)— NT_010918 (334.8 kb)—NT_010859 (1966 kb)—pcen (Table 1Table 1bTable 1c).

Table 1 Candidate genes and STSs on 18p11.2
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Authors and Affiliations

  1. National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA

    G D Reyes, L E Esterling, W Corona, D Ferraren, D Y Rollins, M Padigaru, T Yoshikawa & S D Detera-Wadleigh

  2. National Institute of Molecular Biology and Biotechnology, University of the Philippines, Diliman, Quezon City, Philippines

    G D Reyes

  3. National Institute of Molecular Biology and Biotechnology, College of Science, University of the Philippines, Diliman, Quezon City, Philippines

    V D Monje

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  1. G D Reyes
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  2. L E Esterling
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  3. W Corona
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  4. D Ferraren
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  5. D Y Rollins
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  6. M Padigaru
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  7. T Yoshikawa
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  8. V D Monje
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  9. S D Detera-Wadleigh
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Correspondence to S D Detera-Wadleigh.

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Reyes, G., Esterling, L., Corona, W. et al. Map of candidate genes and STSs on 18p11.2, a bipolar disorder and schizophrenia susceptibility region. Mol Psychiatry 7, 337–339 (2002). https://doi.org/10.1038/sj.mp.4001000

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