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Control of transcription and neurological diseases

Molecular Psychiatry volume 4, pages 112–114 (1999)Cite this article

Abstract

In this article we underline the importance of the transcriptional control of dopaminergic receptors in animal behavior. In particular, genetically modified animals, for some retinoid receptors, show locomotor phenotypes which resemble those found in dopamine receptor mutants. The finding that the dopamine D2 receptor contains in its promoter sequences that are responsive to retinoids points to a possible role of these molecules in the establishment of neuropathological diseases.

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Authors and Affiliations

  1. Laboratory of Molecular Neuroscience, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France

    E Borrelli

  2. Laboratory of Molecular Genetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France

    P Chambon

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  1. E Borrelli
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  2. P Chambon
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Correspondence to E Borrelli.

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Borrelli, E., Chambon, P. Control of transcription and neurological diseases. Mol Psychiatry 4, 112–114 (1999). https://doi.org/10.1038/sj.mp.4000491

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