Abstract
Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.
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Reynolds, G., Dalton, C. Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?. Mol Psychiatry 3, 192–195 (1998). https://doi.org/10.1038/sj.mp.4000374
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DOI: https://doi.org/10.1038/sj.mp.4000374