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Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders

Molecular Psychiatry volume 3, pages 169–174 (1998)Cite this article

Abstract

We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH*2 allele (χ2 = 8.30, d.f. = 1; P = 0.004) and lack of the TH*1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.

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Authors and Affiliations

  1. Department of Neuroscience, Istituto Scientifico H San Raffaele, University of Milano (Italy) School of Medicine, Milano, Italy

    A Serretti, F Macciardi, C Cusin, M Verga, S Pedrini & E Smeraldi

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  1. A Serretti
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  2. F Macciardi
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  3. C Cusin
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  4. M Verga
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  5. S Pedrini
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  6. E Smeraldi
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Serretti, A., Macciardi, F., Cusin, C. et al. Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. Mol Psychiatry 3, 169–174 (1998). https://doi.org/10.1038/sj.mp.4000373

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  • DOI: https://doi.org/10.1038/sj.mp.4000373

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