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ICE and apoptosis


This issue features an article by Lynch, Shivers and colleagues (pages 227–238) which presents a novel, cell-permeable cysteine protease inhibitor, boc-aspartyl(OMe)-fluoromethylketone (boc-Asp-CH2F, abbreviated BAF). This inhibitor is an important new tool available to the research community and may represent a harbinger of a new class of chemicals useful in the treatment of human disease. In order to understand the value of BAF, we need to take a step back and examine the current concepts on the role of apoptosis in human disease.

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Wolozin, B. ICE and apoptosis. Mol Psychiatry 2, 184–187 (1997).

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