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Sildenafil improves quality of life in men with heart failure and erectile dysfunction


Patients with congestive heart failure (CHF) have specific factors that enhance the risk for erectile dysfunction (ED), such as low cardiac output and the use of drugs with vasodilator effect. ED can negatively affect interpersonal relationships and self-esteem, with significant impact on the quality of life. We hypothesized that the improvement of the sexual dysfunction would enhance the quality of life of individuals with systolic heart failure. This is a prospective study of 12 male CHF patients using a fixed dose of sildenafil during 1 month. Patients were included if they had left ventricular ejection fraction lower than 40% documented by echocardiography and International Index of Erectile Function (IIEF) score lower than 21. The effect of sildenafil in quality of life was evaluated by the Minnesota questionnaire. Improvement in ED was assessed using the IIEF. The mean IIEF5 score was 9.6 (±3.8) before the use of sildenafil and 19.3 (±4.3) after sildenafil (P=0.0001). The mean Minnesota score was 28.75 (±21) before treatment and 12.75 (±10.1) after the intervention (P=0.012). In conclusion, the sexual function improvement provided by sildenafil enhances quality of life in individuals with systolic heart failure.

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Figure 1


  1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB . Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61.

    CAS  Article  PubMed  Google Scholar 

  2. Moreira ED, Lisboa Lobo CF, Villa M, Nicolosi A, Glasser DB . Prevalence and correlates of erectile dysfunction in Salvador, northeastern Brazil: a population-based study. Int J Impot Res 2002; 14(Suppl 2): S3–S9.

    Article  PubMed  Google Scholar 

  3. Althof S . The patient with erectile dysfunction: psychological issues. Nurse Pract 2000; (Suppl): 11–13.

    Article  Google Scholar 

  4. Katz SD, Parker JD, Glasser DB, Bank AJ, Sherman N, Wang H et al. Efficacy and safety of sildenafil citrate in men with erectile dysfunction and chronic heart failure. Am J Cardiol 2005; 95: 36–42.

    CAS  Article  PubMed  Google Scholar 

  5. Benet AE, Melman A . The epidemiology of erectile dysfunction. Urol Clin North Am 1995; 22: 699–709.

    CAS  PubMed  Google Scholar 

  6. Hak T, Willems D, van der Wal G, Visser F . A qualitative validation of the Minnesota Living with Heart Failure Questionnaire. Qual Life Res 2004; 13: 417–426.

    Article  PubMed  Google Scholar 

  7. Rhoden EL, Teloken C, Sogari PR, Vargas Souto CA . The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. Int J Impot Res 2002; 14: 245–250.

    CAS  Article  PubMed  Google Scholar 

  8. Crapo RO, Casaburi R, Coates AL, Enright PL, MacIntyre NR, Mckay RT et al. ATS: statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166: 111–117.

    Article  Google Scholar 

  9. Webster LJ, Michelakis ED, Davis T, Archer SL . Use of sildenafil for safe improvement of erectile function and quality of life in men with New York Heart Association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial. Arch Intern Med 2004; 164: 514–520.

    CAS  Article  PubMed  Google Scholar 

  10. Bestetti RB, Muccilo G . Clinical course of Chagas' heart disease: a comparison with dilated cardiomyopathy. Int J Cardiol 1997; 60: 187–193.

    CAS  Article  PubMed  Google Scholar 

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Correspondence to D Freitas.

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Freitas, D., Athanazio, R., Almeida, D. et al. Sildenafil improves quality of life in men with heart failure and erectile dysfunction. Int J Impot Res 18, 210–212 (2006).

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  • impotence
  • quality of life
  • heart failure
  • urologic and male genital disease

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