Abstract
The objective of this study is to describe the eligibility, consumption, efficacy and patient satisfaction when treating men with diabetes with Sildenafil. The study is a prospective, self-reported, flexible-dose study. In total, 45 patients with diabetes (type 1 or 2), complaining of erectile dysfunction, were treated with Sildenafil over a 12-week period. Efficacy was assessed using a patientlog, a general satisfaction questionnaire and the International Index of Erectile Function (IIEF). Of 326 men, 192 reported erectile dysfunction, 79 did not fulfil the criteria for Sildenafil treatment and 49 declined to participate. In the group of 33 (age 45–75 y, mean±s.d.: 58.1±7.2) completing the study, erectile function was significantly improved (P<0.0001). A total of 12 patients (36.4%) experienced no treatment effect at all. Eligibility and desire for treatment was low. Sildenafil is far from being a ‘cure all’ in the treatment of ED in diabetes.
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References
NIH Consensus Development Panel on Impotence: Impotence. JAMA 1993; 270: 83–90.
Hakim LS, Goldstein I . Diabetic sexual dysfunction. Endocrin Metab Clin N Am 1996; 25: 379–400.
Litwin MS, Nied RJ, Dhanani N . Health related quality of life in men with erectile dysfunction. J Gen Intern Med 1998; 13: 159–166.
Feldman HA et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol 1994; 151: 54–61.
Ellenberg M . Impotence in diabetes: the neurologic factor. Ann Intern Med 1971; 75: 213–219.
Kolodny RC, Kahn CB, Goldstein HH, Barnett DM . Erectile dysfunction in diabetic men. Diabetes 1974; 23: 306–309.
McCulloch DK et al. Prevalence of diabetic impotence. Diabetologia 1980; 18: 279–283.
Klein R et al. Prevalence of erectile dysfunction in people with longterm IDDM. Diabetes Care 1996; 19: 135–141.
Bancroft J, Gutierrez P . Erectile dysfunction in males with and without diabetes mellitus: a comparative study. Diabetes Med 1996; 13: 84–89.
Bemelmans BLH et al. Erectile dysfunction in diabetic men: the neurological factor revisited. J Urol 1994; 151: 884–889.
Close CF, Ryder RE . Impotence in diabetes. Diabetes Metab Rev 1995; 11: 279–285.
Romeo JH, Seftel AD, Madhun ZT, Aron DC . Sexual function in men with diabetes type 2: association with glycaemic control. J Urol 2000; 163: 788–791.
Goldstein I et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998; 338: 1397–1404.
Korenman SG . New insights into erectile dysfunction: a practical approach. Am J Med 1998; 105: 135–144.
Boolel M, Gepi-Attee S, Gingell JC, Allen MJ . Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1996; 78: 257–261.
Boolell M et al. Sildenafil (Viagra) is an efficacious oral therapy in diabetic patients with erectile dysfunction. Int J Impot Res 1996; 8: 186.
Rendell MS, Rajfer J, Wicker PA, Smith MD . Sildenafil for treatment of erectile dysfunction in men with diabetes. JAMA 1999; 281: 421–426.
Price DE et al. Sildenafil: study of a novel oral treatment for erectile dysfunction in diabetic men. Diabetes Med 1998; 15: 821–825.
Palumbo F et al. Sildenafil: efficacy and safety in daily clinical experience. Eur Urol 2001; 40: 176–180.
Lepore G, Nosari I . Efficacy of oral Sildenafil in the treatment of erectile dysfunction in diabetic men with positive response to intracavernosal injection of Alprostadil. Diabetes Care 2001; 24: 409–411.
Vibe-Petersen J, Behrend L, Jørgensen T, Perrild H . The prevalence of erectile dysfunction in a male diabetic population (Abstract). Diabetologia 1999; 42: A1140.
Rosen RC et al. The International Index of Erectile Function (IIEF): a multidimentional assessment of erectile dysfunction. Urology 1997; 49: 822–830.
Karlawish JHT, Casarett D . Sildenafil for diabetic men with erectile dysfunction. JAMA 1999; 282: 940–941.
Lipschultz LI, Kim ED . Treatment of erectile dysfunction in men with diabetes. JAMA 1999; 281: 465–466.
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The study was completed with an independent grant from Pfizer A/S.
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Behrend, L., Vibe-Petersen, J. & Perrild, H. Sildenafil in the treatment of erectile dysfunction in men with diabetes: demand, efficacy and patient satisfaction. Int J Impot Res 17, 264–269 (2005). https://doi.org/10.1038/sj.ijir.3901302
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DOI: https://doi.org/10.1038/sj.ijir.3901302
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