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Effects of sildenafil on ocular perfusion demonstrated by color Doppler ultrasonography

International Journal of Impotence Research volume 16, pages 244–248 (2004)Cite this article

Abstract

The aim of this study was to investigate the effects of sildenafil on ocular hemodynamics by color Doppler ultrasonography (CDU). In all, 38 patients with erectile dysfunction diagnosed by International Index of Erectile Function (IIEF) and Sexual Health Inventory of Men (SHIM) scores were included into the study. After taking 100 mg of oral sildenafil citrate, all patients underwent CDU examination of central retinal artery at 60 and 75 min and CDU examination of cavernosal artery at 20, 60 and 75 min. All of the side effects during and after the test were also recorded. The mean cavernous artery peak systolic flow velocity increased significantly after sildenafil. However, no significant change was determined in central retinal artery flow parameters including peak systolic flow velocity, end-diastolic flow velocity, resistive index, pulsatility index, volume and diameter. Five patients experienced ocular side effects. No significant change was observed in retinal artery CDU measurements of patients having ocular side effects. Sildenafil has no effect on ocular hemodynamics on the basis of CDU. Ocular side effects may be the result of other changes in retinal photoreceptors rather than the ocular circulation.

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References

  1. Viera AJ, Clenney TL, Shenenberger DW, Green GF . Newer pharmacologic alternatives for erectile dysfunction. Am Fam Physician 1999; 60: 1159–1166.

    CAS  PubMed  Google Scholar 

  2. Ballard SA et al. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isoenzymes. J Urol 1998; 159: 2164–2171.

    Article  CAS  Google Scholar 

  3. Beavo JA . Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 1995; 75: 725–748.

    Article  CAS  Google Scholar 

  4. Marmor MF . Sildenafil (Viagra) and ophthalmology. Arch Ophthalmol 1999; 117: 518–519.

    Article  CAS  Google Scholar 

  5. Marmor MF, Kessler R . Sildenafil (Viagra) and ophthalmology. Surv Ophthalmol 1999; 44: 153–162.

    Article  CAS  Google Scholar 

  6. Laties AM, Fraunfelder FT . Ocular safety of Viagra (sildenafil citrate). Trans Am Ophthalmol Soc 1999; 97: 115–125.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Food and Drug Administration Joint Clinical Review. Study 148-004: phase I investigator-blind, placebo-controlled, evaluation of safety, toleration and pharmacokinetics of sildenafil following escalating single oral doses in healthy male volunteers, pp 96–98.

  8. Goldstein I et al. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 1998; 338: 1397–1404.

    Article  CAS  Google Scholar 

  9. Zrenner E . No cause for alarm over retinal side effects of sildenafil. Lancet 1999; 353: 340–341.

    Article  CAS  Google Scholar 

  10. Gabrieli CB et al. Subjective visual halos after sildenafil (Viagra) administration: electroretinographic evaluation. Ophthalmology 108: 877–881.

    Article  CAS  Google Scholar 

  11. Vobig MA et al. Retinal side effects of sildenafil. Lancet 1999; 353: 375.

    Article  CAS  Google Scholar 

  12. Kretschmann U et al. Short time influences of sildenafil on visual function. Invest Ophtalmol Vis Sci 1999; 40: 693.

    Google Scholar 

  13. Arslan D et al. A new method for the evaluation of erectile dysfunction: sildenafil plus Doppler ultrasonography. J Urol 2001; 166: 181–184.

    Article  CAS  Google Scholar 

  14. Sponsel WE et al. Sildenafil increases ocular perfusion. Int Ophthalmol 2001; 23: 355–358.

    Article  Google Scholar 

  15. Grunwald JE, Siu KK, Jacob SS, Dupont J . Effect of sildenafil citrate (Viagra) on the ocular circulation. Am J Ophthalmol 2001; 131: 751–755.

    Article  CAS  Google Scholar 

  16. Hayreh SS . Effect of sildenafil citrate (Viagra) on the ocular circulation. Am J Ophtalmol 2002; 133: 169–170.

    Article  Google Scholar 

  17. Petrig BL, Riva CE, Hayreh SS . Laser Doppler flowmetry and optic nerve head blood flow. Am J Ophthalmol 1999; 127: 413–425.

    Article  CAS  Google Scholar 

  18. Dundar SO et al. Effects of sildenafil on ocular hemodynamics. Eye 2001; 15: 507–510.

    Article  CAS  Google Scholar 

  19. Bill A, Sperber GO . Control of retinal and choroidal blood flow. Eye 1990; 4: 319–325.

    Article  Google Scholar 

  20. Trew DR, Smith SE . Postural studies in pulsatile ocular blood flow: I. Ocular hypertension and normotension. Br J Ophthalmol 1991; 75: 66–70.

    Article  CAS  Google Scholar 

  21. Riva CE, Grunwald JE, Petrig BL . Reactivity of the human retinal circulation to darkness: a laser Doppler velocimetric study. Invest Ophthalmol Vis Sci 1983; 24: 737–740.

    CAS  PubMed  Google Scholar 

  22. Cavalotti C, Artico M, Pescosolido N, Feher J . Age related changes in rat retina. Jpn J Ophthalmol 2001; 45: 68–75.

    Article  Google Scholar 

  23. Elsner AE, Burns SA, Weiter JJ . Cone photopigment in older subjects: decreased optical density in early age-related macular degeneration. J Opt Soc Am A Opt Image Sci Vis 2002; 19: 215–222.

    Article  Google Scholar 

  24. Adler R et al. Cell death in age related macular degeneration. Mol Vis 1999; 5: 31.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey

    E Kurtulan, I Celebi, G Aslan & A A Esen

  2. Department of Radiology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey

    A Gulcu & M Secil

Authors
  1. E Kurtulan
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  2. A Gulcu
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  3. M Secil
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  4. I Celebi
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  5. G Aslan
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  6. A A Esen
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Correspondence to M Secil.

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Kurtulan, E., Gulcu, A., Secil, M. et al. Effects of sildenafil on ocular perfusion demonstrated by color Doppler ultrasonography. Int J Impot Res 16, 244–248 (2004). https://doi.org/10.1038/sj.ijir.3901189

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  • DOI: https://doi.org/10.1038/sj.ijir.3901189

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