Abstract
The present investigation was designed to evaluate the effect of histamine on isolated rings of horse deep dorsal penile vein. Under precontracted or basal conditions, histamine evoked an endothelium-independent contraction. Preincubation of the vein rings with the selective H1 receptor antagonist, mepyramine, shifted the concentration–response curve for histamine and to the H1 receptor agonist 2-pyridylethylamine to the right in a competitive manner. Pretreatment with cimetidine, a specific H2 receptor antagonist, did not modify the pEC50 and maximal contraction of the histamine response. Cimetidine and propranolol failed to induce a change in the relaxation caused by dimaprit, the H2 receptor agonist. Histamine contraction was unaffected by thioperamide, the specific H3 receptor antagonist. (R)-α-methylhistamine, the H3 receptor agonist, also induced contractions which persisted in the presence of either thioperamide or tetrodotoxin. These data indicate that horse deep dorsal penile vein shows an endothelium-independent contraction response to histamine, mainly mediated by H1 receptors.
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References
Nehra A, Goldstein I, Pabby A. . Mechanisms of venous leakage: a prospective clinicopathological correlation of corporal function and structure. J Urol 1996 156: 1320–1329.
Borowitz E, Barnea O. . Hemodynamic mechanisms of penile erection. IEEE Trans Biomed Eng 2000 47: 319–326.
Carati CJ, Creed KE, Keogh EJ. . Vascular changes during erection in the dog. J Physiol 1988 400: 75–88.
Esen AA et al . Contractility changes of the deep dorsal penile vein due to serotonin. J Urol 1997 158: 234–237.
Ballard SA et al . Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isoenzymes. J Urol 1998 159: 2164–2171.
Simonsen U, Contreras J, García-Sacristán A, Martínez AC. . Effect of sildenafil on non-adrenergic non-cholinergic neurotransmission in bovine penile small arteries. Eur J Pharmacol 2001 412: 155–169.
Recio P, López PG, Fernández JLG, García-Sacristán A. . Pharmacological characterization of adrenoceptors in horse corpus cavernosum penis. J Auton Pharmacol 1997 17: 199–206.
Simonsen U et al . Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries. J Urol 1997 157: 2356–2360.
Simonsen U et al . Adrenoceptor-mediated regulation of the contractility in horse penile resistance arteries. J Vasc Res 1997 34: 90–102.
Kirkeby HJ, Fahrenkrug J, Holmquist F, Ottesen B. . Effects of noradrenaline, 5-hydroxytryptamine and histamine on human penile cavernous tissue and circumflex veins. Int J Impot Res 1989 1: 181–188.
Fontaine J, Schulman CC, Wespes E. . Postjunctional alpha-1 and alpha-2-like activity in human isolated deep dorsal vein of the penis. Br J Pharmacol 1987 89: 493–499.
Adaikan PG, Lau LC, Ratnam SS. . Physio-pharmacology of human penile erection-autonomic/nitrergic neurotransmission and receptors of the human corpus cavernosum. Asian Pac J Pharmacol 1991 6: 213–217.
Andersson KE, Wagner G. . Physiology of penile erection. Physiol Rev 1995 75: 191–236.
Kim YC et al . Characterization and function of histamine receptors in corpus cavernosum. J Urol 1995 153: 506–510.
Cara AM et al . The role of histamine in human penile erection. Br J Urol 1995 75: 220–224.
Martínez AC et al . Endothelium-independent relaxation induced by histamine in human dorsal penile artery. Clin Exp Pharmacol Physiol 2000 27: 500–507.
Martínez AC et al . Evidence of histamine receptor function in isolated horse penile dorsal arteries. Life Sci 2000 67: 1355–1368.
Martínez AC, García-Sacristán A, Rivera L, Benedito S. . Biphasic response to histamine in rabbit penile dorsal artery. J Cardiovasc Pharmacol 2000 36: 737–743.
Arunlakshana O, Schild HO. . Some quantitative uses of drug antagonism. Br J Pharmacol 1959 14: 48–58.
Tallarida RJ, Murray RB. . Manual of pharmacologic calculations with computer programs. Springer-Verlag: New York 1984 pp 30.
Schoeffter P, Godfraind T. . Characterization of histamine-induced contraction in rat isolated aorta. Eur J Pharmacol 1991 197: 193–200.
Hill SJ et al . International Union of Pharmacology. XIII. Classification of histamine receptors. Am J Physiol 1997 49: 253–278.
Arrang JM, Garbarg M, Schwartz JC. . Auto-inhibition of brain histamine release by a novel class (H3) of histamine receptor. Nature 1983 302: 832–837.
Ea-Kim L, Oudart N. . A highly potent and selective H3 agonist relaxes rabbit middle cerebral artery, in vitro Eur J Pharmacol 1988 150: 393–396.
Martínez AC et al . Histamine receptors in isolated bovine oviductal arteries. Eur J Pharmacol 1997 326: 163–173.
Gruetter CA, Lemke SM, Valentovic MA, Szarek JL. . Evidence that histamine is involved as a mediator of endothelium-dependent contraction induced by A23187 in bovine intrapulmonary vein. Eur J Pharmacol 1994 257: 275–283.
Venugopalan CS et al . Biphasic responses of equine colonic vessel rings to vasoactive inflammatory mediators. J Auton Pharmacol 1998 18: 231–237.
Acknowledgements
The authors thank the Guadalajara and Madrid Municipal Slaughterhouse for kindly supplying fresh tissue. This study was financed by grant from DGES (PM98/0088) Ministerio de Educación y Ciencia, Spain.
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Martínez, A., Prieto, D., Hernández, M. et al. Contractile response of horse deep dorsal penile vein to histamine. Int J Impot Res 14, 85–92 (2002). https://doi.org/10.1038/sj.ijir.3900830
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DOI: https://doi.org/10.1038/sj.ijir.3900830