Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject


In several studies we have recently demonstrated that orgasm induces prolactin secretion in healthy males and females. This suggests that prolactin may form a feedback regulator of the refractory period following orgasm. To examine this position we investigated the prolactin response of a healthy multi-orgasmic male subject. Blood was drawn continuously during masturbation-induced orgasm. The prolactin response of the case-subject was compared with that of nine healthy adult men with a normal refractory period. The case-subject showed no prolactin response to three orgasms. Data from this multi-orgasmic subject support the hypothesized role of plasma prolactin in contributing to sexual-satiation mechanisms.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1


  1. Hummer M et al . Sexual disturbance during clozapine and haloperidol treatment for schizophrenia. Am J Psychiat 1999 156: 631–633.

    CAS  PubMed  Google Scholar 

  2. Rosen RC, Lane RM, Menza M. . Effects of SSRIs on sexual function: a critical review. J Clin Psychopharm 1999 19: 67–85.

    Article  CAS  Google Scholar 

  3. Krueger T et al . Neuroendocrine and cardiovascular response to sexual arousal and orgasm in men. Psychoneuroendocrinology 1998 23: 401–411.

    Article  Google Scholar 

  4. Exton MS et al . Cardiovascular and endocrine alterations after masturbation-induced orgasm in women. Psychosom Med 1999 61: 280–289.

    Article  CAS  Google Scholar 

  5. Exton MS et al . Coitus stimulates prolactin secretion in healthy subjects. Psychoneuroendocrinology 2001 26: 287–294.

    Article  CAS  Google Scholar 

  6. Exton NG et al . Neuroendocrine response to film-induced sexual arousal in men and women. Psychoneuroendocrinology 2000 25: 187–199.

    Article  CAS  Google Scholar 

  7. Dunn ME, Trost JE. . Male multiple orgasm: a descriptive study. Arch Sex Behav 1989 18: 377–387.

    Article  CAS  Google Scholar 

  8. Krüger THC, Haake P, Hartmann U, Schedlowski M, Exton MS. . Prolactin release following orgasm: a feedback control of sexual arousal? Neurosci Biobehav Review 2002 26: 31–44

    Article  Google Scholar 

  9. Koppelman MCS et al . Effect of Bromocriptine on affect and libido in hyperprolactinemia. Am J Psychiat 1987 144: 1037–1041.

    Article  CAS  Google Scholar 

  10. Drago F, Lissandrello CO. . The ‘low dose’ concept and the paradoxical effects of prolactin on grooming and sexual behavior. Eur J Pharmacol 2000 405: 131–137.

    Article  CAS  Google Scholar 

Download references


The work contained in this manuscript was supported by a grant from the ‘Deutsche Forschungsgemeinschaft’ (Sche 341/10-1).

Author information

Authors and Affiliations


Corresponding author

Correspondence to M S Exton.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Haake, P., Exton, M., Haverkamp, J. et al. Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject. Int J Impot Res 14, 133–135 (2002).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • sexual arousal
  • prolactin
  • multi-orgasmic
  • model
  • refractory period
  • neuroendo-crinology

This article is cited by


Quick links