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Bisphenol A inhibits penile erection via alteration of histology in the rabbit

International Journal of Impotence Research volume 13, pages 309–316 (2001)Cite this article

Abstract

Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative dose of 900 mg/kg). Four and 8 weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals compared to the control animals. Histologically, thickening of tunica albuginea, subtunical deposition of fat and decreased sinusoidal space with consequent increase of trabecular smooth muscle content were observed in the BPA-treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis.

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Acknowledgements

This study was supported by Korea University Medical Science Research Center Grant 1999 and Ministry of Education in Korea.

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Authors and Affiliations

  1. Department of Urology, Korea University College of Medicine, Seoul, Korea

    DG Moon, DJ Sung, J Cheon & JJ Kim

  2. Department of Pathology, Korea University College of Medicine, Seoul, Korea

    YS Kim

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  1. DG Moon
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  2. DJ Sung
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  3. YS Kim
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  4. J Cheon
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Correspondence to JJ Kim.

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Moon, D., Sung, D., Kim, Y. et al. Bisphenol A inhibits penile erection via alteration of histology in the rabbit. Int J Impot Res 13, 309–316 (2001). https://doi.org/10.1038/sj.ijir.3900734

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