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Ferula harmonis ‘zallouh’ and enhancing erectile function in rats: efficacy and toxicity study

International Journal of Impotence Research volume 13, pages 247–251 (2001)Cite this article

Abstract

Ferula harmonis, which is locally called ‘zallouh’ in the Middle East, is used as an aphrodisiac as it is reputed to enhance male sexual behavior, however, there is no scientific verification. In this study, the oil extracted from the seeds of Ferula harmonis was tested for its efficacy in enhancing erectile function and toxicity in male rats. The sexual activities assessed by penile erection index were dose dependent. The ED50 (12.03 mg/kg) was 880 times less than the LD50 (10.6 g/kg). However, when doses ranging from 0.05, 0.5 to 2 g/kg were given daily for 28 days, acute and subacute toxicity were observed. There was a decrease in total body weight, hepatomegaly, atrophic testis, significant decrease in hemoglobin and red blood cell count. In addition, there was a significant decrease in cholesterol level. All the above indicate that the crude oil from the plant Ferula harmonis can enhance erectile function, however, it becomes toxic if it is used for a long period of time. Further studies are underway to isolate and identify the active ingredients and their exact mechanisms of action.

International Jounal of Impotence Research (2001) 13, 247–251

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References

  1. Turner LA et al. Twelve-month comparison of two treatments for erectile dysfunction: self-injection versus external vacuum devices. Urology 1992 39, 139–144

    Article  CAS  Google Scholar 

  2. Bells DS, Cutter GR, Hayne VB, Lloyd LK . Factors predicting efficacy of phentolamine–papaverine intracorporeal injection for treatment of erectile dysfunction in diabetic male. Urology 1992 40, 36–40

    Article  Google Scholar 

  3. Baum N, Randrup E, Junot D, Hass S . Prostaglandin E1 versus sex therapy in the management of psychogenic erectile dysfunction. Int J Impot Res 2000 12, 191–194

    Article  CAS  Google Scholar 

  4. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ . Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1996 73, 257–261

    Article  Google Scholar 

  5. Benassi-Benelli A, Ferrari F, Quarantotti BP . Penile Erection induced by apomorphine and N-n-propyl-norapomorphine in rats. Arch Int Pharmacodyn 1979 242, 241–247

    CAS  PubMed  Google Scholar 

  6. Ang HH, Sim MK . Effects of Eurycoma longifolia jack on penile erection index and homosexual mounting in rats. Pharmaceut Sci 1997 3, 117–119

    CAS  Google Scholar 

  7. Ahmed AA . Sesquiterpene coumarins and sesquiterpene from Ferula sinaica Phytochem 1999 50, 109–112

    Article  CAS  Google Scholar 

  8. Ignathkov Via, Akhmedkhodzhaeva KHS, Babichev VN . The effects of tefestrol on the secretion of luteinizing hormone from the hypophysis. Farmakol Toksikol 1990 53, 37–38

    Google Scholar 

  9. Cotran RS, Kumar V, Collins T . Robbins Pathologic Basis of Disease, 6th edn. WB Saunders Co: Philadelphia 1999 pp 1016

  10. Aqel MB, Alkhalil S, Afifi F . Relaxant effects of Ferula sinaica extract on the uterine smooth muscle of rabbit and guinea pig. J Ethnopharmcol 1991 31, 291–297

    Article  CAS  Google Scholar 

  11. Aqel MB, Alkhalil S, Afifi F, Aleisawi D . Relaxant effects of Ferula sinaica root extract on rabbit and guinea pig smooth muscle. J Ethnopharmcol 1991 31, 373–381

    Article  CAS  Google Scholar 

  12. Bredt DS, Snyder SH . Nitric oxide: a physiologic messenger molecule. Ann Rev Biochem 1994 63, 175–195

    Article  CAS  Google Scholar 

  13. Takeyoshi M, Anai S, Shinoda K . Hepatic alpha (2u)-globulin mRNA levels and diethylstilbesterol-associated testicular atrophy in rats. Reprod Toxicol 2000 14, 355–357

    Article  CAS  Google Scholar 

  14. Cohen PG . The role of estradiol in the maintenance of secondary hypogonadism in males in erectile dysfunction. Med Hypotheses 1998 50, 331–333

    Article  CAS  Google Scholar 

  15. Gunther RT . The Greek Herbal of Dioscroides Hafner: New York 1959 pp 323

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Authors and Affiliations

  1. ARAGEN Biotechnology, Naor, Jordan

    TS El-Thaher

  2. Faculty of Pharmacy and Medical Technology, The University of Petra, Amman, Jordan

    KZ Matalka

  3. Delas Natural Products, Naor, Jordan

    HA Taha

  4. The Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan

    AA Badwan

Authors
  1. TS El-Thaher
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  2. KZ Matalka
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  3. HA Taha
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  4. AA Badwan
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Correspondence to AA Badwan.

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El-Thaher, T., Matalka, K., Taha, H. et al. Ferula harmonis ‘zallouh’ and enhancing erectile function in rats: efficacy and toxicity study. Int J Impot Res 13, 247–251 (2001). https://doi.org/10.1038/sj.ijir.3900706

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  • DOI: https://doi.org/10.1038/sj.ijir.3900706

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