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Current approaches and perspectives in human keratinocyte-based gene therapies

Gene Therapy volume 11, pages S57–S63 (2004)Cite this article

Abstract

Inherited and acquired disorders are liable to treatment with somatic gene therapy. The skin, and in particular epidermal cells, are particularly suited to genetic manipulation and follow-up of therapeutic effects. Cutaneous gene therapy may be effective for skin defects and systemic abnormalities. The robust basic and preclinical data available today would support the application of keratinocyte-based gene therapy to patients.

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Acknowledgements

We are indebted to Almudena Holguín and Blanca Duarte for excellent technical support, Isabel de Los Santos and Pilar Hernandez, Soledad Moreno for art work and Jesus Martinez for animal care. Our work is supported by DEBRA (UK) Foundation (GM), and the ‘Association Française contre les Myopathies’ (AFM) (GM) and the Programme Hospitalier de Recherche Clinique (GM) SAF- BMC-2001-1018 from Ministerio de Ciencia y Tecnología to JL Jorcano, FIS 01/0556 from Ministerio de Sanidad y Consumo to F Larcher and CAM 08.6/0004 to M Del Rio.

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Authors and Affiliations

  1. Epithelial Damage, Repair and Tissue Engineering Project. CIEMAT. Avenida Complutense 22, Madrid, Spain

    M Del Rio, J L Jorcano & F Larcher

  2. Fundación Marcelino Botín for Gene Therapy, INSERM U634, Faculty of Medicine, Nice, France

    Y Gache & G Meneguzzi

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  1. M Del Rio
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  2. Y Gache
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  4. G Meneguzzi
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  5. F Larcher
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Del Rio, M., Gache, Y., Jorcano, J. et al. Current approaches and perspectives in human keratinocyte-based gene therapies. Gene Ther 11 (Suppl 1), S57–S63 (2004). https://doi.org/10.1038/sj.gt.3302370

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