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Post-intervention vessel remodeling

Gene Therapy volume 9, pages 1487–1491 (2002)Cite this article

Abstract

By-pass surgery and percutaneous transluminal (coronary) angioplasty, PT(C)A, are standard techniques for the treatment of vascular occlusions. Their usefulness is limited by by-pass graft failure and restenosis occuring after the procedures. Twenty percent of patients treated with PTCA/PTA need a new revascularization procedure within 6 months, despite a successful procedure. Stents are used to prevent restenosis in selected lesions, but in-stent restenosis also remains an important clinical problem. In this review we discuss progress of gene therapy for the treatment of post-PT(C)A restenosis, in-stent restenosis and by-pass graft stenosis over the last 2 years (2000–2002).

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Acknowledgements

This study was supported by grants from Finnish Academy and Sigrid Juselius Foundation. We thank Ms Marja Poikolainen for preparing the manuscript.

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Authors and Affiliations

  1. AI Virtanen Institute, University of Kuopio, Kuopio, Finland

    J Rutanen, H Puhakka & S Ylä-Herttuala

  2. Department of Medicine, University of Kuopio, Kuopio, Finland

    S Ylä-Herttuala

  3. Gene Therapy Unit, University of Kuopio, Kuopio, Finland

    S Ylä-Herttuala

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Rutanen, J., Puhakka, H. & Ylä-Herttuala, S. Post-intervention vessel remodeling. Gene Ther 9, 1487–1491 (2002). https://doi.org/10.1038/sj.gt.3301866

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