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Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan

Leukemia volume 22, pages 428–432 (2008)Cite this article

In acute myeloid leukemia (AML), t(8;21)(q22;q22) translocation is one of the most common karyotype abnormalities, occurring in 7–8% of adult patients.1 This change is closely associated with AML-M2 subtype in the French-American-British (FAB) classification, a type of AML with high complete remission (CR) rate (85–90%) and favorable survival rate.1, 2, 3 Studies conducted in western countries have demonstrated that survival is prolonged when consolidation chemotherapies comprising high-dose cytarabine are administered.2

A research group from the Cancer and Leukemia Group B reported that clinical characteristics of t(8;21) AML could alter depending on ethnicity, suggesting that direct adoption of treatment strategies based on clinical studies conducted in western countries to Japanese patients may not be advisable.4 A recent study from Japan focused mainly on the clinical impact of cytogenetics.5 Information on clinical characteristics and optimal treatments, such as the clinical impact of high-dose cytarabine, thus remains unavailable for Japanese patients.

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Acknowledgements

We thank all the staff and resident members of the participating institutions. A complete list of participating institutions appears in the Appendix.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan

    H Narimatsu, A Sawamoto & I Sugiura

  2. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    H Narimatsu, M Yanada & T Naoe

  3. Department of Hematology/Oncology, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

    T Yokozawa & C Kato

  4. Department of Hematology, Meitetsu Hospital, Nagoya, Japan

    H Iida & H Sao

  5. Department of Medicine, Fujita Health University School of Medicine, Toyoake, Japan

    M Tsuzuki & N Emi

  6. Department of Hematology, Komaki City Hospital, Komaki, Japan

    M Hayakawa

  7. Department of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan

    T Takeo

  8. Department of Hematology, Yamanashi Prefectual Central Hospital, Kofu, Japan

    M Iino

  9. Department of Hematology, Okazaki City Hospital, Okazaki, Japan

    T Ichihashi & T Yamaguchi

  10. Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan

    H kiyoi

  11. Department of HSCT Data Management, Nagoya University School of Medicine, Nagoya, Japan

    R Suzuki

Authors
  1. H Narimatsu
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  2. T Yokozawa
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  3. H Iida
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  4. M Tsuzuki
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  5. M Hayakawa
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  6. T Takeo
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  7. M Iino
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  8. T Ichihashi
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  9. C Kato
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  10. A Sawamoto
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  11. H Sao
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  12. M Yanada
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  13. N Emi
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  14. H kiyoi
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  15. T Yamaguchi
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  16. T Naoe
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  17. R Suzuki
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  18. I Sugiura
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Corresponding author

Correspondence to H Narimatsu.

Appendix

Appendix

This study was conducted at the following institutions: National Hospital Organization Nagoya Medical Center, Nagoya; Toyohashi Municipal Hospital, Toyohashi; Meitetsu Hospital, Nagoya; Fujita Health University Hospital, Toyoake; Komaki City Hospital, Komaki; Yokkaichi Municipal Hospital, Yokkaichi; Yamanashi Prefectural Central Hospital, Yamanashi; Okazaki City Hospital, Okazaki, Japan.

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Narimatsu, H., Yokozawa, T., Iida, H. et al. Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. Leukemia 22, 428–432 (2008). https://doi.org/10.1038/sj.leu.2404905

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