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mRNA stability control: a clandestine force in normal and malignant hematopoiesis

Leukemia volume 21, pages 1158–1171 (2007)Cite this article

Abstract

This review addresses the scope of influence of mRNA decay on cellular functions and its potential role in normal and malignant hematopoiesis. Evidence is emerging that leukemic oncogenes and hematopoietic cytokines interact with mRNA decay pathways. These pathways can co-regulate functionally related genes through specific motifs in the 3′-untranslated region of targeted transcripts. The steps that link external stimuli to transcript turnover are not fully understood, but include subcellular relocalization or post-transcriptional modification of specific transcript-stabilizing or -destabilizing proteins. Improper functioning of these regulators of mRNA turnover can impede normal cellular differentiation or promote cancers. By delineating how subsets of transcripts decay in synchrony during normal hematopoiesis, it may be possible to determine whether this post-transcriptional regulatory pathway is hijacked in leukemogenesis.

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Acknowledgements

The author thanks Drs Daniel Johnson and Roberto Gherzi for helpful comments on this paper. This work was supported by a grant from the Hillman Foundation.

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    R A Steinman

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Steinman, R. mRNA stability control: a clandestine force in normal and malignant hematopoiesis. Leukemia 21, 1158–1171 (2007). https://doi.org/10.1038/sj.leu.2404656

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