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Acute myeloid leukemia cells constitutively express the immunoregulatory enzyme indoleamine 2,3-dioxygenase

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  1. Mellor AL, Munn DH . Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 1999; 20: 469–473.

    Article  CAS  Google Scholar 

  2. Frumento G, Rotondo R, Tonetti M, Damonte G, Benfatti U, Ferrara GB . Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med 2002; 196: 459–468.

    Article  CAS  Google Scholar 

  3. Grohmann U, Fallarino F, Puccetti P . Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 2003; 24: 242–248.

    Article  CAS  Google Scholar 

  4. Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 2002; 297: 1867–1870.

    Article  CAS  Google Scholar 

  5. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D . Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103: 4619–4621.

    Article  CAS  Google Scholar 

  6. Uyttenhove C, Pilotte L, Théate I, Stroobant V, Colau D, Parmentier N et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003; 9: 1269–1274.

    Article  CAS  Google Scholar 

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Correspondence to A Curti.

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Curti, A., Aluigi, M., Pandolfi, S. et al. Acute myeloid leukemia cells constitutively express the immunoregulatory enzyme indoleamine 2,3-dioxygenase. Leukemia 21, 353–355 (2007).

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