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Molecular pathways in follicular lymphoma

Leukemia volume 21, pages 18–29 (2007)Cite this article

Abstract

Follicular lymphoma (FL) is one of the most common B-cell non-Hodgkin's lymphomas. The initiating genetic event found in ∼90% of FL is the t(14;18), causing constitutive expression of the antiapoptotic BCL-2 protein. The exact secondary alterations leading to full FL development are still poorly defined. In this review, we address (i) the genetic pathways associated with tumorigenesis and progression of FL, (ii) the role of micro-environmental factors with emphasis on B-cell receptor ligands and (iii) lymphoma models in mice and what they teach us about lymphomagenesis in man.

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Acknowledgements

We thank Dr Mijntje Aarts as past co-worker for some of the data and stimulating discussions, Febe van Maldegem for thoroughly reading this paper, David J de Gorter for helpful discussions, Drs Herbert C Morse and Michael Teitell for personal communications and Elina S te Boekhorst for technical assistance.

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  1. Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    R J Bende, L A Smit & C J M van Noesel

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Bende, R., Smit, L. & van Noesel, C. Molecular pathways in follicular lymphoma. Leukemia 21, 18–29 (2007). https://doi.org/10.1038/sj.leu.2404426

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