Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Angiogenesis and mast cells in Hodgkin lymphoma

Leukemia volume 19, pages 2360–2362 (2005)Cite this article

TO THE EDITOR

Hodgkin lymphoma (HL) differs from other lymphomas because the malignant cells, the Hodgkin and Reed–Sternberg (HRS) cells, are in minority and the majority of the tissue consists of surrounding benign cells, for example, eosinophilic granulocytes and mast cells, fibrosis and a varying number of microvessels. It has recently been reported that angiogenesis correlates to poor prognosis in HL.1

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

References

  1. Korkolopoulou P, Thymara I, Kavantzas N, Vassilakopoulos TP, Angelopoulou MK, Kokoris SI et al. Angiogenesis in Hodgkin's lymphoma: a morphometric approach in 286 patients with prognostic implications. Leukemia 2005; 19: 894–900.

    Article  CAS  Google Scholar 

  2. Molin D, Edstrom A, Glimelius I, Glimelius B, Nilsson G, Sundstrom C et al. Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma. Br J Haematol 2002; 119: 122–124.

    Article  Google Scholar 

  3. Molin D, Fischer M, Xiang Z, Larsson U, Harvima I, Venge P et al. Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease. Br J Haematol 2001; 114: 616–623.

    Article  CAS  Google Scholar 

  4. Ribatti D, Crivellato E, Roccaro AM, Ria R, Vacca A . Mast cell contribution to angiogenesis related to tumour progression. Clin Exp Allergy 2004; 34: 1660–1664.

    Article  CAS  Google Scholar 

  5. Fox SB, Leek RD, Weekes MP, Whitehouse RM, Gatter KC, Harris AL . Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol 1995; 177: 275–283.

    Article  CAS  Google Scholar 

  6. Norrby K . Mast cells and angiogenesis. Apmis 2002; 110: 355–371.

    Article  CAS  Google Scholar 

  7. Doussis-Anagnostopoulou IA, Talks KL, Turley H, Debnam P, Tan DC, Mariatos G et al. Vascular endothelial growth factor (VEGF) is expressed by neoplastic Hodgkin-Reed-Sternberg cells in Hodgkin's disease. J Pathol 2002; 197: 677–683.

    Article  CAS  Google Scholar 

  8. Jundt F, Anagnostopoulos I, Bommert K, Emmerich F, Muller G, Foss HD et al. Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils. Blood 1999; 94: 2065–2071.

    CAS  PubMed  Google Scholar 

  9. Hattori H . Caution should be taken in using CD31 for distinguishing the vasculature of lymph nodes. J Clin Pathol 2003; 56: 638–639.

    Article  Google Scholar 

  10. Vermeulen PB, Gasparini G, Fox SB, Toi M, Martin L, McCulloch P et al. Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 1996; 32A: 2474–2484.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Lila Shokohideh and Majlis Book for their expert technical assistance. This study was supported by The Swedish Cancer Society, Lions Cancer research foundation in Uppsala and FoU-forum in Gävle.

Author information

Authors and Affiliations

  1. Department of Oncology, Radiology and Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    I Glimelius, A Edström, M Fischer, D Molin, R-M Amini & G Enblad

  2. Department of Genetics and Pathology, Rudbeck laboratory, Uppsala University, Uppsala, Sweden

    G Nilsson & C Sundström

Authors
  1. I Glimelius
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Edström
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M Fischer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G Nilsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C Sundström
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D Molin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R-M Amini
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G Enblad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I Glimelius.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Glimelius, I., Edström, A., Fischer, M. et al. Angiogenesis and mast cells in Hodgkin lymphoma. Leukemia 19, 2360–2362 (2005). https://doi.org/10.1038/sj.leu.2403992

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403992

This article is cited by

Search

Advanced search

Quick links