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Higher-grade transformation of follicular lymphoma – a continuous enigma

Leukemia volume 19, pages 1331–1333 (2005)Cite this article

Higher-grade histological transformation is a pivotal event in the natural history of low-grade non-Hodgkin's lymphoma (NHL), typically associated with more aggressive clinical behavior and a rapidly progressive clinical course refractory to treatment and short survival. Better understanding of the pathogenesis of the higher-grade transformation might lead to the identification of new therapeutic approaches that could improve patients' outcome. In this issue of the journal, Davies et al1 evaluated the role of TP53 gene mutations in transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL).1

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Acknowledgements

This work was supported by the Grant RO1 CA109335 from the United States Public Health Service, National Institutes of Health.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA

    I S Lossos

  2. Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, USA

    I S Lossos

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  1. I S Lossos
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Correspondence to I S Lossos.

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Lossos, I. Higher-grade transformation of follicular lymphoma – a continuous enigma. Leukemia 19, 1331–1333 (2005). https://doi.org/10.1038/sj.leu.2403801

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