This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Forestier E, Heim S, Blennow E, Borgstrom G, Holmgren G, Heinonen K et al. Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all children enrolled in the NOPHO-93-AML trial between 1993 and 2001. Br J Haematol 2003; 121: 566–577.
Biondi A, Rovelli A, Cantù-Rajnoldi A, Fenu S, Basso G, Luciano A et al. Acute promyelocytic leukaemia in children: experience of the Italian Pediatric Hematology and Oncology Group (AIEOP). Leukemia 1994; 8: 1264–1268.
Martinez-Climent JA, Lane NJ, Rubin CM, Morgan E, Johnstone HS, Mick R et al. Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo. Leukemia 1995; 9: 95–101.
Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into MRC 10 trial. Blood 1998; 92: 2322–2333.
Raimondi SC, Chang MN, Ravindranath Y, Behm FG, Gresik MV, Steuber CP et al. Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative Pediatric Oncology Group Study – POG8821. Blood 1999; 94: 3707–3716.
Krauter J, Peter W, Pascherberg U, Heinze B, Bergmann L, Hoelzer D et al. Detection of karyotypic aberrations in acute myeloblastic leukaemia: a prospective comparison between PCR/FISH and standard cytogenetics in 140 patients with de novo AML. Br J Hematol 1998; 103: 72–78.
Rowe D, Cotterill SJ, Ross FM, Bunyan DJ, Vickers SJ, Bryon J et al. Cytogenetically cryptic AML1-ETO and CBFβ-Myh11 gene rearrangements: incidence in 412 case of acute myeloid leukaemia. Br J Haematol 2000; 111: 1051–1056.
Byrd JC, Dodge RK, Carrol A, Baer MR, Edward C, Stamberg J et al. Patients with t(8;21)(q22;q22) and acute myeloid leukaemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered. J Clin Oncol 1999; 17: 3767–3775.
Acknowledgements
We thank Professor G Valsecchi for her helpful suggestions, Ms S Disarò for excellent technical assistance, Dr A Leszl for cytogenetic data and Dr C Case for linguistic consultancy. We are grateful to all the clinicians of the participating AIEOP centres for clinical data. We also thank S Fenu, L Sainati, A Cantù Rajnoldi and G Basso for the morphological review. This research was supported by Fondazione Città della Speranza and and Prog.Fin. 2001/01/X/000177 Ministero Salute OBG, MIUR 60-40% and CNR Progetto Oncologia.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Frascella, E., Rondelli, R., Pigazzi, M. et al. Clinical features of childhood acute myeloid leukaemia with specific gene rearrangements. Leukemia 18, 1427–1429 (2004). https://doi.org/10.1038/sj.leu.2403410
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2403410
This article is cited by
-
Analysis of class I and II aberrations in Iraqi childhood acute myeloid leukemia using filter paper cards
Annals of Hematology (2014)
-
MLL partner genes drive distinct gene expression profiles and genomic alterations in pediatric acute myeloid leukemia: an AIEOP study
Leukemia (2011)
-
Immunophenotype signature as a tool to define prognostic subgroups in childhood acute myeloid leukemia
Leukemia (2006)