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BAG3 protein regulates stress-induced apoptosis in normal and neoplastic leukocytes

Leukemia volume 18, pages 358–360 (2004)Cite this article

TO THE EDITOR

Co-chaperone proteins that share the Bcl-2-associated athanogene (BAG) domain are characterized by their interaction with a variety of partners, such as heat shock proteins (Hsp), steroid hormone receptors, Bcl-2, Raf-1 and others, involved in regulating protein folding and a number of cellular processes, including proliferation and apoptosis.1,2 Among BAG family members there is BAG3, also known as CAIR-1 or Bis.2,3,4,5,6 BAG3 forms a complex with Hsp70,1,2,4,6 a protein able to modulate apoptosis by interfering with cytochrome c release, apoptosome assembly and other events in the death process.7,8,9,10,11,12,13,14,15 In addition, BAG3 polypeptide binds to phospholipase C-γ (PLC-γ)4 or Bcl-2 protein.3,5 Due to such interaction with more than one apoptosis-modulating factor, BAG3 can participate in apoptosis regulation. Indeed, its hyperexpression can decrease apoptosis induced via Bax or Fas in the human epithelial cell line HeLa3 or by IL-3 deprivation in the murine hematopoietic cell line 32D.5 Furthermore, we recently showed that BAG3 downmodulation enhances the apoptotic response to chemotherapy in human primary B chronic lymphocytic leukemia cells.16

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Authors and Affiliations

  1. Tumour Institute “Fondazione Sen. Pascale” Naples, Italy

    P Bonelli

  2. Dipartimento di Scienze Farmaceutiche (DIFARMA) University of Salerno, Italy

    A Petrella, A Rosati, R Lerose, M G Pagliuca, M Festa, M C Turco & A Leone

  3. Dipartimento di Biochimica e Biotecnologie Mediche (DBBM) and Area di Ematologia (DACM) University of Naples ‘Federico II’, Italy

    M F Romano

  4. Dipartimento di Scienze e Tecnologie per l'Ambiente ed il Territorio (DiSTAT) University of Molise, Italy

    T Amelio & G Martire

  5. Dipartimento di Medicina Sperimentale e Clinica (DMSC) University of Catanzaro, Italy

    S Venuta

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Correspondence to M C Turco.

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Bonelli, P., Petrella, A., Rosati, A. et al. BAG3 protein regulates stress-induced apoptosis in normal and neoplastic leukocytes. Leukemia 18, 358–360 (2004). https://doi.org/10.1038/sj.leu.2403219

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