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High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis

Leukemia volume 17, pages 2535–2537 (2003)Cite this article

TO THE EDITOR

Genomic abnormalities are emerging as crucial prognostic parameters in multiple myeloma (MM). Deletion of chromosome arm 13q (13q−) is present in 40–60% of tumors and has been recognized as an independent predictor of a dismal prognosis. Using chromosome banding analysis, only about a third of myelomas exhibit an abnormal karyotype. Moreover, evaluable metaphases are missing in up to one-fourth of cases, as shown in large cytogenetic studies. By molecular cytogenetic techniques, for example, comparative genomic hybridization (CGH) or fluorescence in situ hybridization (FISH), genomic changes can be identified in more than 90% of plasma cells primary tumors. While banding analyses fail to identify certain chromosomal aberrations, for example, small deletions or translocations with breakpoints located near the telomere, such abnormalities can be reliably detected by FISH. Therefore, FISH has become the most widely used tool for molecular diagnostics in MM today.

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Acknowledgements

This study was supported by a grant from the Deutsche Krebshilfe to PL (70-3899-Li I). We gratefully acknowledge the centers of the Deutsche Studiengruppe Multiples Myelom and the German-Speaking Myeloma Multicenter Group for their continuous support as well as Katrin Roth and Sibylle Janczik for excellent technical assistance.

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Authors and Affiliations

  1. Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

    P Liebisch, C Wendl, A Wellmann, A Kröber, M Bentz, S Stilgenbauer & H Döhner

  2. Medical Clinic II, University Hospital Eppendorf, Hamburg, Germany

    G Schilling

  3. Med. Klinik und Poliklinik V, University Hospital of Heidelberg, Heidelberg, Germany

    H Goldschmidt

  4. Department of Internal Medicine II, University Hospital of Tübingen, Tübingen, Germany

    H Einsele

  5. Med. Klinik – Innenstadt, Ludwig-Maximilians-Universität, München, Germany

    C Straka

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  1. P Liebisch
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Liebisch, P., Wendl, C., Wellmann, A. et al. High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis. Leukemia 17, 2535–2537 (2003). https://doi.org/10.1038/sj.leu.2403153

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