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t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma

Leukemia volume 17, pages 2032–2035 (2003)Cite this article

Abstract

Recent studies have shown that two recurrent translocations, t(4;14)(p16;q32) and t(11;14)(q13;q32), define distinct entities with different prognosis in multiple myeloma (MM). We addressed the issue of whether these illegitimate IGH rearrangements could contribute to the morphological heterogeneity of the malignant plasma cells (PC). Bone marrow aspirates of 178 untreated MM cases with successful molecular cytogenetics analysis using fluorescence in situ hybridization were reviewed. PC of 25/48 (52%) patients with t(11;14) exhibited a lymphoplasmacytoid morphology. Moreover, 25/27 (93%) of the cases with this morphological profile bore the t(11;14). In addition, both cytogenetics and morphological subtypes shared higher incidence of nonsecretory MM. In contrast, 17 out of 28 cases (61%) with t(4;14) exhibited PC with diffuse chromatin pattern. Interestingly, both t(4;14) translocation and immature morphology correlated with higher incidence of high tumor mass and chromosome 13 abnormality. In conclusion, our results suggest that a particular morphology can be the signature of chromosomal abnormalities in MM.

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Authors and Affiliations

  1. Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Nantes, France

    R Garand, H Avet-Loiseau, F Accard & R Bataille

  2. Service d'Hématologie Clinique, Centre Hospitalier Universitaire, Nantes, France

    P Moreau & J L Harousseau

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  1. R Garand
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  2. H Avet-Loiseau
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  3. F Accard
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  4. P Moreau
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  5. J L Harousseau
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  6. R Bataille
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Garand, R., Avet-Loiseau, H., Accard, F. et al. t(11;14) and t(4;14) translocations correlated with mature lymphoplasmacytoid and immature morphology, respectively, in multiple myeloma. Leukemia 17, 2032–2035 (2003). https://doi.org/10.1038/sj.leu.2403091

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