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Bone marrow transplantation: how important is CD34 cell dose in HLA-identical stem cell transplantation?

Leukemia volume 17, pages 856–858 (2003)Cite this article

Abstract

A recent analysis of Fred Hutchinson Cancer Research Center data has been undertaken to investigate the association of infused CD34 cell dose with various clinical outcomes after HLA-identical transplantation. Separate assessments for unrelated vs related donors and the use of bone marrow or mobilized G-CSF stimulated peripheral blood mononuclear cells (G-PBMC) have been incorporated. The three primary findings are: (1) Higher CD34 dose results in better neutrophil and platelet recovery in all settings. (2) Higher CD34 doses (>8 × 106/kg) are associated with the development of more chronic graft-versus-host disease when using related G-PBMC. (3) Higher CD34 dose is correlated with improved survival after unrelated donor bone marrow transplantation. These data suggest that the CD34 content of a graft can have a significant impact on clinical outcome after allogeneic transplantation, but defining an optimal dose is dependent on both the type of donor and the stem cell source.

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Acknowledgements

This work was supported by NIH Grants HL66947, CA15704, CA18029, DK56465, and HL54881.

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  1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    S Heimfeld

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Heimfeld, S. Bone marrow transplantation: how important is CD34 cell dose in HLA-identical stem cell transplantation?. Leukemia 17, 856–858 (2003). https://doi.org/10.1038/sj.leu.2402893

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