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Death and decoy receptors and p53-mediated apoptosis

Leukemia volume 14, pages 1509–1513 (2000)Cite this article

Abstract

Recently, several tumor necrosis factor receptor 1 (TNF-R1) and Fas-related death receptors have been discovered and include DR3, DR4, DR5 and DR6. These receptors contain an extracellular region containing varying numbers of cysteine-rich domains and an intracellular region that contains the death domain. The death receptors are activated in a ligand-dependent or independent manner and transduce apoptotic signals via their respective intracellular death domains. In addition to death receptors, several decoy molecules have also been identified and include DcR1/TRID, DcR2/TRUNDD, DcR3 and osteoprotegrin (OPG). The decoy molecules do not transduce apoptotic signals but rather compete with the death receptors for ligand binding and thereby inhibit ligand-induced apoptosis. Recent evidence suggests that p53 upregulates the expression of death receptors Fas and DR5, and thus, may mediate apoptosis in part via Fas and/or DR5. However, p53 also regulates the expression of TRAIL decoy receptors DcR1/TRID and DR2/TRUNDD. Although the significance of p53-dependent regulation of decoy receptors remains unclear, evidence suggests that DcR1/TRUNDD appears to inhibit 53-mediated apoptosis. It is, therefore, possible that p53 may blunt its DR5-dependent apoptotic effects by controlling the levels of decoy receptors.

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Authors and Affiliations

  1. Department of Pharmacology, SUNY Upstate Medical University, Syracuse, New York, USA

    MS Sheikh

  2. Division of Basic Sciences, Gene Response Section, NCI, NIH, Bethesda, Maryland, USA

    AJ Fornace Jr

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Sheikh, M., Fornace, A. Death and decoy receptors and p53-mediated apoptosis. Leukemia 14, 1509–1513 (2000). https://doi.org/10.1038/sj.leu.2401865

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