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Regulation of granulopoiesis by transcription factors and cytokine signals

Abstract

The development of mature granulocytes from hematopoietic precursor cells is controlled by a myriad of transcription factors which regulate the expression of essential genes, including those encoding growth factors and their receptors, enzymes, adhesion molecules, and transcription factors themselves. In particular, C/EBPα, PU.1, CBF, and c-Myb have emerged as critical players during early granulopoiesis. These transcription factors interact with one another as well as other factors to regulate the expression of a variety of genes important in granulocytic lineage commitment. An important goal remains to understand in greater detail how these various factors act in concert with signals emanating from cytokine receptors to influence the various steps of maturation, from the pluripotent hematopoietic stem cell, to a committed myeloid progenitor, to myeloid precursors, and ultimately to mature granulocytes.

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Acknowledgements

ACW, AS-B and IPT are supported by an NWO Pioneer Grant. DML is supported by NIH Training Grant CA60441. ADF is a Leukemia Society of America Scholar, and his research is supported by the Children's Cancer Foundation.

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Ward, A., Loeb, D., Soede-Bobok, A. et al. Regulation of granulopoiesis by transcription factors and cytokine signals. Leukemia 14, 973–990 (2000). https://doi.org/10.1038/sj.leu.2401808

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  • DOI: https://doi.org/10.1038/sj.leu.2401808

Keywords

  • transcription factors
  • granulopoiesis
  • cytokine receptor
  • C/EBPα
  • PU.1
  • G-CSF-R

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