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CD34: To select or not to select? That is the question

Leukemia volume 14, pages 773–776 (2000)Cite this article

Abstract

Recent evidence suggests that expression of CD34 on the cell membrane does not always correlate with stem cell activity. In the mouse, there is a highly quiescent population of stem cells that lacks CD34 expression, but has full reconstituting capacity. The current review addresses the discovery of a similar population of dormant CD34-negative human hematopoietic stem cells. This information casts some uncertainty on the benefits of CD34+ cell isolation for stem cell transplantation, until more is known about the novel CD34-negative stem cell population. Methods designed to achieve removal of specific mature blood cell lineages might prove to be most advantageous in the future.

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Acknowledgements

The research in Dr Nolta's laboratory is supported by the NIH NHLBI (SCOR #P50-HL54850), NIH NIDDK (RO1 DK 53041), The John Connell Gene Therapy Foundation, and a Career Development Award from the CHLA Research Institute.

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Authors and Affiliations

  1. Division of Research Immunology/Bone Marrow Transplantation, Children's Hospital Los Angeles, Dept Pediatrics, University of Southern California School of Medicine, 4650 Sunset Blvd, Mailstop 62, Los Angeles, 90027, CA, USA

    MA Dao & JA Nolta

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Correspondence to JA Nolta.

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Dao, M., Nolta, J. CD34: To select or not to select? That is the question. Leukemia 14, 773–776 (2000). https://doi.org/10.1038/sj.leu.2401781

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