Abstract
We have investigated the possible role of anti-tumor antibody detected in a case of follicular lymphoma which demonstrated the spontaneous reduction of leukemic tumor cells. The tumor cells genotypically had monoclonal rearrangements of the immunoglobulin J H and C κ genes, but phenotypically exhibited surface IgG, A, κ and λ (κ λ dual positivity). The culture study revealed that IgGλ, at least, was derived from the serum, and IgAκ was expressed intrinsically. Furthermore, the positive correlation between the densities of both surface light chains on two-color flow cytometry, the rosette formation study and its inhibition test by the Fcγ fragment suggested that the serum IgGλ combined with some antigens on the tumor-cell surface via its Fab portion and with the Fcγ receptor of macrophages via its Fc portion. From these findings, we regarded the present case as an anti-tumor antibody-coated lymphoma. In addition, the phagocytic study disclosed that the serum-derived IgGλ, at least, might have induced the phagocytosis of circulating lymphoma cells by macrophages. In conclusion, the existence of the anti-tumor antibody-coated lymphoma may be helpful in clarifying the immunological mechanism of the spontaneous regression occasionally seen in lymphomas.
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Nakano, M., Kawanishi, Y., Kuriya, Y. et al. Spontaneous reduction of leukemic lymphoma cells possibly by anti-tumor antibody-mediated phagocytosis; a κ λ-dual-positive B cell lymphoma. Leukemia 14, 278–284 (2000). https://doi.org/10.1038/sj.leu.2401667
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DOI: https://doi.org/10.1038/sj.leu.2401667