Abstract
A case of cutaneous T cell lymphoma associated with mild eosinophilia and rise of IgE levels is reported. A population of CD3−CD4+ cells was observed in the peripheral blood. After activation, these purified CD3−CD4+ cells showed a Th2 pattern of cytokine production, secreting higher levels of IL-5 and IL-4 and lower levels of IFN-γ compared to the patient’s and controls’ CD3+CD4+ cells. Moreover, high levels of IL-5 and soluble CD30, a marker of Th2 cell activation, were detected in the patient’s serum.
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Brugnoni, D., Airò, P., Tosoni, C. et al. CD3−CD4+ cells with a Th2-like pattern of cytokine production in the peripheral blood of a patient with cutaneous T cell lymphoma. Leukemia 11, 1983–1985 (1997). https://doi.org/10.1038/sj.leu.2400839
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DOI: https://doi.org/10.1038/sj.leu.2400839
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