Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

New insight on the role of extrachromosomal retroviral DNA

Leukemia volume 11, pages 1395–1399 (1997)Cite this article

Abstract

During infection with different retroviruses, high levels of unintegrated extrachromosomal DNA accumulate in infected cells. While extrachromosomal linear DNA is the immediate precursor of the integrated provirus, the function, if any, of extrachromosomal circular DNA has been unclear. Several groups have attempted to address the possible function, activity, and importance of this unintegrated DNA during the life cycle of retroviruses and the course of retroviral-associated diseases. This review summarizes recent work in this field and tries to analyze some aspects of extrachromosomal forms of retroviral DNA and their possible application as a molecular biological tool.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    A Cara

  2. Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, MD 21201, USA

    MS Reitz Jr

Authors
  1. A Cara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. MS Reitz Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cara, A., Jr, M. New insight on the role of extrachromosomal retroviral DNA. Leukemia 11, 1395–1399 (1997). https://doi.org/10.1038/sj.leu.2400776

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2400776

Keywords

This article is cited by

Search

Advanced search

Quick links