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Molecular Cytogenetics

Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm

Abstract

Deletion of the long arm of human chromosome 6 in acute lymphoblastic leukemia (ALL) has been shown by cytogenetic studies in 4–11% of cases. To characterize further the region of deletion and to precisely establish its frequency, we studied loss of heterozygozity (LOH) in 120 children with ALL using polymorphic markers located from the 6q14-15 chromosomal band to the telomere. LOH was detected in eight patients. A single region of LOH, flanked distally by D6S1594 and proximally by D6S301 was detected. These DNA markers are separated by 6 cM and are approximately located at the 6q21-22 band. Our present results delineate a region that is likely to contain a tumor-suppressor gene involved in a subset of childhood ALLs.

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Gérard, B., Cavé, H., Guidal, C. et al. Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm. Leukemia 11, 228–232 (1997). https://doi.org/10.1038/sj.leu.2400566

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  • DOI: https://doi.org/10.1038/sj.leu.2400566

Keywords

  • acute lymphoblastic leukemia
  • loss of heterozygosity
  • chromosome 6q
  • tumor suppressor

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